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Fri Dec 22, 2006 9:09 pm |
Ohhh Since I'm just getting really into these forums, I decided to do a little research onto Dark Circles. Well here we go:
(Taken from a website)
Puffiness or bagging of the skin under the eyes, together with rings, wrinkles and discoloration (dark circles) under the eye, present a serious cosmetic problem for a great portion of the population. Worse, these are some of the toughest problems to eliminate. There are good reasons for this. The tissues around the eye are very thin, sometimes just a few cells thick. The capillaries that supply blood to this area are among the most fragile and easily disrupted in the entire body and are therefore readily bruised and affected by aging. Dark circles under the eye are due to the accumulation of hemoglobin and its pigmented degradation products-biliverdin, bilirubin and iron-in the dermis and epidermis. Removal of these waste materials from this area is also extremely limited. Hence, as we age, the overall ability of the body to maintain the integrity of the tissues, i.e. the blood supply and the lymphatic system around the eyes, becomes increasingly compromised.
To date there has been precious little one could do about this unsightly problem. Now, innovative research has brought new options to those seeking solutions to these problems. New skin-care products based on this research help restore tone and youthful appearance to this particularly fragile zone around the eye.
One of these ingredients, hesperidin methyl chalcone, decreases capillary permeability. That is, it decreases the tendency of disrupted capillaries to leak fluid and hemoglobin out of the small blood vessels into the spaces between cells. These pigmented molecules are what lend a dark-colored appearance to the skin.
Another ingredient, dipeptide valyl-tryptophane (VW) improves lymphatic circulation. One of the functions of the body's lymphatic system is removal of unwanted materials from the tissues surrounding the blood vessels. If capillary permeability increases and lymphatic drainage decreases in the lax tissue around the eyes, then pigmented materials tend to concentrate and find little or no avenue for escape.
A third ingredient, Lipopeptide Pal-GQPR, improves firmness and elasticity and decreases inflammation. Firming up the tissues around the eye helps to decrease puffiness, and decreasing inflammation tends to reduce the redness and soreness that often accompany other unwanted disruptions of the health of these tissues. Often, inflammation is caused by nothing more than ultraviolet radiation (exposure to the sun).
A clinical test of the materials listed above was conducted in 20 female volunteers age 40-60, with chronic puffiness under the eyes. Application of a gel containing 3% of a mixture of those ingredients twice a day for 56 days resulted in a significant reduction in the thickness of swollen periorbital tissue. By day 56, fully 70% of the volunteers experienced a reduction in periorbital edema. A majority of the volunteers reported a smoothing of the eye contour, a reduction in swelling, and a decongestant effect.
As anyone who has experienced puffiness around the eyes knows, results of this kind are truly remarkable.
Another ingredient found useful in combination is two so-called matrikines, Pal-GHK and Pal-GQPR, with hydroxy-succinimide (NHS) and the flavonoid chrysin.
Testing has shown that Pal-GHK and Pal- GQPR help to reinforce firmness and tone up the skin around the eye. They also facilitate the elimination of pigments responsible for dark circle formation, as well as reduce local inflammation by inhibiting prostaglandins to about the same degree as is obtained with aspirin.
Expanding on what was mentioned above; dark circles under the eye are due to the accumulation of hemoglobin and its pigmented degradation products (biliverdin, bilirubin and iron) in the dermis and epidermis. Laboratory tests have proven that chrysin stimulates a form of the enzyme UGT, leading to the clearance of bilirubin, a yellow pigment molecule. NHS solubilizes this pigment, allowing it to be eliminated.
In a clinical trial, 22 female volunteers applied a gel containing 2% of the mixture just described to the contour of one eye, and a placebo cream to the contour of the other eye, for a period of 56 days. Using sophisticated image analysis, it was determined that the violaceous colors of dark circles under the treated eye were decreased significantly in 60% and 70% of the subjects, respectively. In the responders, the average decrease was almost 20%. Hence, the daily application of this mixture achieves a remarkable improvement in the appearance of dark circles under the eyes.
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Ingredients known to help alleviate hereditary dark circles.
Palmitoyl oligopeptide and Palmitoyl tetrapeptide-3:
Two synthetic fragments of the collagen molecule, these peptides work to stimulate collagen production in the deep layers of the skin. Increased collagen production helps to repair flaws like fine lines and wrinkles on the surface of the skin for a younger, smoother look.
These peptides are found most often in high-end anti-wrinkle creams and serums. Dermalex contains them because of their synergestic effect. Combined with the other active ingredients, these peptides help to make dark circles fade away and helps keep them from coming back.
Dipeptide-2 (dipeptide valyl-tryptophane (VW):
Dipeptide-2 is composed of valine (q.v.) and tryptophan (q.v.). It is classed as an amino acid and is used as a miscellaneous skin-conditioning agent. It is also known by the trade name, Dipeptide VW of Sederma.
This ingredient assists with perking up and correcting poor drainage, by increasing the lymphatic exchange and achieving proper circulation of the extra cellular fluids. This is achieved by inhibiting the angiotensin-converting enzyme (ACE).
Palmityol tetrapeptide-3 (Pal-GQPR):
Palmitoyl tertrapeptide-3 is the reaction product of palmitic acid (q.v.) and a synthetic peptide, containing glycine, glutamine, proline and arginine. It is classed as a protein and is used as a miscellaneous skin-conditioning agent. It is also known as N-Palmitoyl Rigin by the Sederma company of France.
This ingredient is used to counteract skin slackening and to perk up and increase the firmness of the fragile skin area around the eye. It decreases irritation that could lead to puffiness.
Hesperidin Mathyl Chalcone:
Hesperidin methyl chalcone is a flavinoid derived from citrus like oranges and lemons. Hesperidin helps to reduce capillary permeability - which means it helps prevent the tiny blood vessels in the skin around your eyes from leaking. It is this leakage which leads to the dark bruise-like discolorations we call dark circles.
Hesperidin is also an anti-inflammatory and helps to reduce puffiness and swelling.
In addition, hesperidin is thought to have the following activities: anti-allerginic, vasoprotective (protecting the circulatory system) and anti-carcinogenic.
Chrysin:
Chrysin is a powerful bioflavinoid extracted from many plants. Chrysin is a potent antioxidant that possesses vitamin-like effects in the body. Chrysin's antioxidant potential has been shown by its ability to inhibit xanthine oxidase and consequently suppress the formation of uric acid and certain reactive oxygen species. It may also, under some conditions, inhibit lipid peroxidation.
Chrysin has been shown to induce an anti-inflammatory effect, which greatly aids in reducing the appearance in dark under eye circles. This anti-inflammatory action is due at least partially to a strong vasodilation effect.
Chrysin has shown promise as a vasorelaxant, a property that may enhance the vasoprotective effects of hesperidin.
Cucumber extract:
Long used as a home remedy for dark circles, cucumber contains both bleaching and soothing properties. These virtues are harnessed in their most concentrated form in cucumber extract. It doesn't spoil and is much easier to apply to the relevant areas than slices of cucumber.
Combinations of Ingredients:
Haloxyl:hydroxysuccinimide, chrysin, palmitoyl oligopeptide, palmitoyl tetrapeptide-3 or 7
Eyeliss:hesperidine methyl chalcone, di-peptide valvl-tryphtophane(VW) or di-peptide 2, and the lipopeptide Pal-GQPR
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Eyeliss is found to be helpful in reducing the appearance of puffiness.
Taken from some site I can't remember:
• Eyeliss: “EYELISS was proven to significantly reduce wrinkles in up to 56% of participants, while reducing puffiness and bags in up to 70 percent of participants”
• “It also markedly improved skin firmness and elasticity”
• “Ageless Eyes is…packed with all the ingredients needed to help restore youth and vitality to tired, stressed, and aging eyes!”
• “The product smoothes the contours of the eyes: 62% satisfaction; The product has a decongestant effect: 52% satisfaction; The product moisturizes the skin: 86% satisfaction.”
• “The skin is softer: 71% satisfaction; The product has a soothing effect: 71% satisfaction.”
• ”Eyeliss is ‘proven’ to significantly reduce wrinkles in up to 56 percent of participants, while reducing puffiness and bags in up to 70 percent of participants.”
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Haloxyl:
Before and afters:
http://nodarkcircles.com/trials.htm
Using a panel of 22 female volunteers, the study measured the intensity of the pigmentation present as rings or circles under the eyes after 56 days of twice daily treatment with a cream containing 2% HALOXYL™ or a placebo. Using image analysis, the area under the eyes was measured for changes in the color parameters L*, a* (Red /Green) and b* (Blue/Yellow) and analyzed relative to the subject’s natural complexion. Note: A reduction in the red and blue coloration indicates a lessening in discoloration of the skin.
Results:
72% OF THE VOLUNTEERS SHOWED A DECREASE IN THE RED COLOR
Color intensity was reduced on average by 19.5% … and as much as 47%
63% OF THE VOLUNTEERS SHOWED A DECREASE IN THE BLUE COLOR
Color intensity was reduced on average by 19 % … and as much as 45%
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In conclusion, I think that products with Haloxyl are very beneficial for hereditary dark circles and products with eyeliss are very beneficial for puffiness.
Products with 10% Haloxyl: Milexin MD (http://nodarkcircles.com/index.htm) |
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Fri Dec 22, 2006 9:09 pm |
Sorry guys I really just wanted to get that out before i go to bed (which is now) so i'll edit it tommorow. |
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Fri Dec 22, 2006 9:17 pm |
This sounds like it's worth an investigation!. Thanks Parentsaver, as one who suffers from 'dark circle syndrome' I am always interested in something new. |
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Sat Dec 23, 2006 12:10 pm |
Well I think the best part is just looking at the before and afters . |
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Sat Dec 23, 2006 4:36 pm |
Parentsaver wrote: |
Well I think the best part is just looking at the before and afters . |
I stopped looking at those ages ago because it is too easy these days to manipulate photos. Even a lay person can use a basic photo editing program to make some very appropriate changes. |
_________________ Skin: Over 60, ex combination now sensitive, Cellcosmet |
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Sat Dec 23, 2006 5:28 pm |
bushy wrote: |
Parentsaver wrote: |
Well I think the best part is just looking at the before and afters . |
I stopped looking at those ages ago because it is too easy these days to manipulate photos. Even a lay person can use a basic photo editing program to make some very appropriate changes. |
I totally agree! Alot of times you can tell the lighting is different, which will throw more or less shadows on the face. Even if someone says the photos are untouched, that doesn't mean the lighting was exactly the same as the before shot. |
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Sat Dec 23, 2006 6:06 pm |
Well I mean they stated that "The method used was image analysis, conducted on photographs taken under standardized conditions."
And if lighting can change the way my dark circles look, then i'd be forever grateful. YOu don't really have dark circles if you can find a lighting that hides your dark circles. You just have deep set eyes. |
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Mon Dec 25, 2006 1:10 pm |
another educational post! |
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Thu Mar 28, 2024 7:26 pm |
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