Article: Why some Treatments Rescue Aging Skin 6/08
EDS Skin Care Forums Forum Index » Skin Care and Makeup Forum

free skin care · Sun Jun 15, 2008 11:52 pm

This is a very good (and short) article on Retin-A, injectible fillers like Restylane and Juvederm, and carbon dioxide laser resurfacing.

Quote:

Why Some Treatments Rescue Aging Skin
ScienceDaily (Jun. 2, 2008)

Fine wrinkles, deeper creases, saggy areas around the mouth and neck – the sights in the mirror that make baby boomers wince – are not inevitable. They result from a structural breakdown inside the skin that some existing treatments effectively counteract by stimulating the growth of new, youthful collagen, University of Michigan scientists say.

Quote:

The researchers report an emerging picture of collagen collapse and possible renewal, based on more than a decade of studies, in the May issue of Archives of Dermatology.

The article draws on dozens of studies since the early 1990s, conducted primarily by U-M dermatologists, to explain why three types of available skin treatments are effective: topical retinoic acid, carbon dioxide laser resurfacing and injections of cross-linked hyaluronic acid.

See this link for the rest...please copy and paste the link if the EDS redirect does not work for you.

http://www.sciencedaily.com/releases/2008/05/080528152141.htm

Editing to add:

Here is the abstract from the May release of the Archives of Dermatology:

Quote:

Looking Older

Fibroblast Collapse and Therapeutic Implications
Gary J. Fisher, PhD; James Varani, PhD; John J. Voorhees, MD

Arch Dermatol. 2008;144(5):666-672.

Skin appearance is a primary indicator of age. During the last decade, substantial progress has been made toward understanding underlying mechanisms of human skin aging. This understanding provides the basis for current use and new development of antiaging treatments. Our objective is to review present state-of-the-art knowledge pertaining to mechanisms involved in skin aging, with specific focus on the dermal collagen matrix. A major feature of aged skin is fragmentation of the dermal collagen matrix. Fragmentation results from actions of specific enzymes (matrix metalloproteinases) and impairs the structural integrity of the dermis. Fibroblasts that produce and organize the collagen matrix cannot attach to fragmented collagen. Loss of attachment prevents fibroblasts from receiving mechanical information from their support, and they collapse. Stretch is critical for normal balanced production of collagen and collagen-degrading enzymes. In aged skin, collapsed fibroblasts produce low levels of collagen and high levels of collagen-degrading enzymes. This imbalance advances the aging process in a self-perpetuating, never-ending deleterious cycle. Clinically proven antiaging treatments such as topical retinoic acid, carbon dioxide laser resurfacing, and intradermal injection of cross-linked hyaluronic acid stimulate production of new, undamaged collagen. Attachment of fibroblasts to this new collagen allows stretch, which in turn balances collagen production and degradation and thereby slows the aging process. Collagen fragmentation is responsible for loss of structural integrity and impairment of fibroblast function in aged human skin. Treatments that stimulate production of new, nonfragmented collagen should provide substantial improvement to the appearance and health of aged skin

http://archderm.ama-assn.org/cgi/content/abstract/144/5/666

free skin care · Mon Jun 16, 2008 6:21 am

"In another 2007 study, the U-M team tested lotions containing retinol, a form of Vitamin A found in many skin-care products, and found it significantly reduced wrinkles and skin roughness in elderly skin by promoting new collagen."

Thanks for the article. I'm thinking that retinol is about as good as retin A? I've read that the prescription retin a was better but maybe not? There is just too much information on this forum for me!

free skin care · Mon Jun 16, 2008 12:46 pm

bodiukein wrote:

"In another 2007 study, the U-M team tested lotions containing retinol, a form of Vitamin A found in many skin-care products, and found it significantly reduced wrinkles and skin roughness in elderly skin by promoting new collagen."

Thanks for the article. I'm thinking that retinol is about as good as retin A? I've read that the prescription retin a was better but maybe not? There is just too much information on this forum for me!

Retinols are actually much weaker than Retin-A

free skin care · Tue Jun 17, 2008 5:16 pm

Thanks for the great article!

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