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Wed Jul 23, 2008 3:11 pm  |
| Interesting pictures, edenfield. The person has had an obvious improvement in her wrinkles and skin structure. Can you please give some additional information about the source of these pictures (I assume these are not private pictures), what strength of retinol has been used, which brand etc.? Thank you. |
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Female, 40, Norway. Normal/dry skin, starting to see signs of aging. Staples: Glycolic acid cleanser, SkinCeuticals Phloretin CF, Revaleskin, NIA24. |
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Wed Jul 23, 2008 3:47 pm |
| I would also like to know how frequently it was used, and if it was retinol or retinoic acid. |
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No longer answering PM's due to numerous weird messages. |
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Wed Jul 23, 2008 3:47 pm |
It's .4% retinol, in a generic cream emulsion.
I think application was daily. lemme check |
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Wed Jul 23, 2008 3:49 pm |
here we go
Patients: The study population comprised 36 elderly subjects (mean age, 87 years), residing in 2 senior citizen facilities.
Intervention: Topical 0.4% retinol lotion or its vehicle was applied at each visit by study personnel to either the right or the left arm, up to 3 times a week for 24 weeks.
Conclusions: Topical retinol improves fine wrinkles as-
sociated with natural aging. Significant induction of gly-
cosaminoglycan, which is known to retain substantial wa-
ter, and increased collagen production are most likely
responsible for wrinkle effacement. With greater skin ma-
trix synthesis, retinol-treated aged skin is more likely to
withstand skin injury and ulcer formation along with im-
proved appearance. |
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Wed Jul 23, 2008 3:51 pm |
| Quote: |
Topical retinoic acid and tazarotene, both approved for the treatment of photoaging, are not suitable for use in geriatric populations either because they consistently induce skin irritation at application sites.4,12,15
All-trans-retinol is a precursor to retinoic acid. When applied to human skin, it penetrates and is sequentially oxidized to retinoic acid, causing retinoic acid–like effects. 16 However, compared with retinoic acid, the ability of retinol to induce skin irritation is notably less, at least according to a 4-day patch test (an occlusive treatment). 16,17 Thus, retinol has the potential to deliver retinoic acid–like effects to human skin with improved tolerability. We report herein a geriatric clinical study (patients 80 years or older only) assessing the effectiveness of topical retinol in effacing fine wrinkling as a clinical end point for reversal of skin atrophy. |
| Quote: |
| Retinol was formulated in the laboratory of 1 of the investigators (G.J.F.) by combining a 41% retinol solution in 55% polysorbate 20 in sufficient proportions with fragrance-free Norwegian Formula Neutrogena Body Moisturizer (Ortho-Neutrogena Co, Los Angeles, Calif ) to yield a 0.4% retinol lotion. |
http://archderm.ama-assn.org/cgi/reprint/143/5/606.pdf
There is some VERY interesting stuff in this article, particularly what results they saw at various phases...definitely worth reading.
Thanks for sharing, Edenfield! |
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No longer answering PM's due to numerous weird messages. |
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Wed Jul 23, 2008 6:13 pm |
Nice to see it in pics........now if I could only see results like that in my face  |
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Wed Jul 23, 2008 6:51 pm |
| babymax24 wrote: |
| Nice to see it in pics........now if I could only see results like that in my face |
Seriously...you and me both!!  |
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No longer answering PM's due to numerous weird messages. |
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Thu Jul 24, 2008 2:06 am |
| the last picture looks like magic, the arms become firm, and no wrinkle! |
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-------My skin type = Dry skin-------- |
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Thu Jul 24, 2008 2:34 am |
| bethany wrote: |
| babymax24 wrote: |
| Nice to see it in pics........now if I could only see results like that in my face |
Seriously...you and me both!! |
That's what I thought, too. I have yet to see such results in my face even though I have beeen using retinol (and now retinoic acid) regularly for many months. |
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Female, 40, Norway. Normal/dry skin, starting to see signs of aging. Staples: Glycolic acid cleanser, SkinCeuticals Phloretin CF, Revaleskin, NIA24. |
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Thu Jul 24, 2008 2:58 am |
| Oh boy, I am rubbing Tazorac on my arms as I write this! WoW~! As I am beginning menopause, the most profound change I've seen (besides hair loss) is the crepe-ness, wrinkling, and dry looking skin on my arms...ok liver, brace yourself! Thanks edenfield for posting! |
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Vehicle is a 1952 scratch and dent model....olive-ish, dry skin, long curly gray hair. Staples: Tazorac, 2mm Dermaroller, Anti Aging Light Stim, Devita Sunscreens, homemade C serums, some positive affirmations and whatever else it takes! Kicking and screaming the whole way... |
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Thu Jul 24, 2008 5:47 am |
| thank you edenfield and bethany for posting the photos and the article! |
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31, combo - oily, breakout-prone, fair complexion, sensitive and prone to rosacea |
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| Fri Apr 19, 2024 12:07 am |
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