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Wed Mar 04, 2009 8:14 am |
ScotsLass wow this is truly worth figuring out. Thank you for the links - I will try to find my way thru the Formulator at Elsom today and give an update later. Thank God I have a job that doesn't interfere with my EDS research
batwhirl would you please share your uber active serum with all of us!! |
_________________ mid 40's, blonde, blue eyes, normal skin, DIY skin regime, AALS - biggest problem undereye - getting much better with AALS & DIY serums. |
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Wed Mar 04, 2009 9:57 am |
ScotsLass wrote: |
I came across an interesting synthesized tetrapeptide that is encapsulated in a liposomal system from LotionCrafter.com. It's called Decorinyl and sounds ideal for mature skin that is losing firmness and elasticity. It's not cheap at $10.95 for 0.25 oz, but my guess is you do not need to use very much in a formulation to reach optimum concentration levels (thanks to it's delivery system!). If anyone tries this active in one of their DIY potions (before LotionCrafter discontinues it), please share your experience here!
DECORINYL™ -www.lotioncrafter.com/store/Decorinyl-trade;-pr-16614.html
Decorinyl™ is a synthesized tetrapeptide which mimics the sequences of decorin that bind to collagen fibrils. It has been shown to regulate fibrillogenesis and control fibril growth, improving firmness and elasticity of the skin, ensuring uniformity of fibril diameter and spacing of collagen fibrils. In effect, it replaces the non-functional decorin encountered as the skin ages, and also sustains a superior moisture profile.
Fibrillogenesis is an essential process in tissue formation, but must be controlled and regulated in order to avoid excessive bundle-like aggregation of collagen. The fibrillogenesis control is the role of decorin, a small leucine-rich proteoglycan, which is associated with collagen fibrils at specific binding sites in the protein core, controlling fibril dimensions, the uniformity of their diameter and their regular spacing.
Aging skin contains a truncated form of decorin, which lacks binding regions with collagen fibrils, producing a negative effect on the elasticity on the skin. Decorinyl™ is a mimic peptide of these binding sequences that has been proven to regulate fibrillogenesis, control collagen fibril diameter and increase skin suppleness.
Decorinyl™ has been incorporated into a liposomal system for enhanced penetration, stability and efficacy. It is recommended for cosmetic formulations designed for mature skin where an improvement of suppleness and strength of skin is desired. It may be used in emulsions, gels and other formulations. |
Hi ScottsLass,
I have this on my think about it list also! I keep a binder with my current ingredients and those that I am thinking about:-) |
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Wed Mar 04, 2009 10:01 am |
Alley wrote: |
ScotsLass wow this is truly worth figuring out. Thank you for the links - I will try to find my way thru the Formulator at Elsom today and give an update later. Thank God I have a job that doesn't interfere with my EDS research
batwhirl would you please share your uber active serum with all of us!! |
Let's see if this works,
Hi Alley, it's in an excel spreed sheet and distorts if I copy and paste here. PM a private email and I'll send it over... |
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Wed Mar 04, 2009 12:31 pm |
Wow wow wow!! If there was an "I'm impressed" emoticon I'd insert it here!
Thanks for all that information ladies. It will take me some time to get through it as I'm new to DIY. I did often wonder how, in formulating my own products, I could be sure that they are actually getting deep into the skin layers as some of the newer products claim. I couldn't understand how simply including actives in a formula meant that they would go deeper into the various layers. I thought they might just stay on top. I have also often wondered how to get the actives into the delivery system of nanosomes and liposomes.
Keep the information coming. It is very much appreciated. |
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Wed May 20, 2009 2:15 pm |
OMG, I have so much to learn!!
I thought it was all just about mixing and voila.... ahhh...
I am so excited about all of this, yey... Just really, I dont know where to start, so much info. |
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Fri Mar 29, 2024 8:38 am |
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