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Tue Jun 16, 2009 7:51 am  |
Skin cancer drug may smooth wrinkles
Cream treatment increases collagen production, researchers say
CHICAGO - A cream used to treat the early signs of skin cancer may erase wrinkles and leave behind younger-looking skin, U.S. researchers said.
They said Valeant Pharmaceuticals' cream Efudex, which is used to treat actinic keratoses, a precancerous form of squamous cell carcinoma, improved the appearance of skin, smoothing out rough spots and wrinkles, improving skin color, and erasing brown spots.
Sachs said the cream appears to be causing a wound healing response that leads to an increase in collagen production, which is improving the appearance of wrinkles.
Read it here.
http://www.msnbc.msn.com/id/31384709/ns/health-aging/
Where can we get this. |
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56 Years, trying to stop the aging process. |
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Tue Jun 16, 2009 9:41 am |
| Alldaychemist has a generic version of Efudex. |
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Tue Jun 16, 2009 9:49 am |
Ya'll better read this 1st, and then move on..  ;
http://spearpharma.com/files/5298%20Fluorouracil%20Pl%20HR.pdf |
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♥I'm flattered by all the lovely PM's, but I don't get here much these days. Please don't be afraid to post your quearies to other DIY members who will be glad to help you (or sell you their wares..lol) Still happy with LED, dermarolling and a DIY antioxidant regime. Peace & Hugs to all.♥ |
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Tue Jun 16, 2009 11:15 am |
| Thanks Kassy. |
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56 Years, trying to stop the aging process. |
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Tue Jun 16, 2009 12:40 pm |
I read about Efudix this morning too: http://www.dailymail.co.uk/health/article-1193221/The-cancer-cream-gets-rid-sun-wrinkles.html
As one comment says: "I was diagnosed last year with solar keratosis and had to use this cream for 8 weeks. This cream should NEVER be used for anything other than for medical purposes. I had open red weeping sores on my chest, felt nausea, tired and generally unwell. It's a strong, toxic powerful drug."
The resulting skin that appears from using it is compared to "raw hamburger meat"! |
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Louise,45,UK.Sunscreen Face/Body L/Term!OCM(Castor/Carrier Oil,Vaculift),MUAC 12.5%,18% TCA,Working Up To SkinObsession 25% TCA/Jessner's.Ageless,Dr Roller,Retin-A 0.05% & 0.1%,AAging Lightstim,CP Serum,Dermawand,Vaculift Face 2 Body 2,Pretika Sonic Brush.Microfibre Cloth.Tua Viso(Broken  ),Palovia (Started 7 April 2011!). |
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Tue Jun 16, 2009 2:13 pm |
| It is a rather drastic treatment just for the sake of skin improvement. I don't see mention of use for non-cancerous or precancerous sites. |
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Enjoying dermalogica with my ASG and Pico toner ** Disclosure: I was a participant without remuneration in promotional videos for Ageless Secret Gold and the Neurotris Pico Emmy event. |
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Tue Jun 16, 2009 3:23 pm |
| Hmmmm, I wonder if it could be diluted. |
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65 Caucasion, history of acne, sagging, some wrinkling, rough texture. Using Dermawand, AALS, Microderm Machine,Copper Peptides |
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Tue Jun 16, 2009 5:48 pm |
These are the "inactive" ingredients in the cream;
purified water, white petrolatum, cetyl alcohol, stearyl alcohol, propylene glycol,
polysorbate 60 and parabens (methyl and propyl.
Those ingredients on their own will smooth and plump the skin, thereby *filling* in the wrinkles somewhat..  |
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♥I'm flattered by all the lovely PM's, but I don't get here much these days. Please don't be afraid to post your quearies to other DIY members who will be glad to help you (or sell you their wares..lol) Still happy with LED, dermarolling and a DIY antioxidant regime. Peace & Hugs to all.♥ |
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Wed Jun 17, 2009 8:52 am |
| Mars wrote: |
| Hmmmm, I wonder if it could be diluted. |
LOL Mars! I was wondering the same thing.  |
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Wed Jun 17, 2009 10:25 am |
| Not for me... It is asking for problems. |
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56 Years, trying to stop the aging process. |
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Fri Apr 02, 2010 5:37 pm |
I have used Efudex (known generically as Fluorouracil) for treating a pre-cancerous spot above my lip. This stuff is nothing to mess with casually. Your skin scabs up and hurts and itches for weeks (yep, just like raw hamburger meat). Then it is red for a few months after. It did get rid of my pre-cancerous spot when freezing it and using Aldara did not.
Approach cautiously. There is more info at:
http://www.essentialdayspa.com/forum/viewthread.php?tid=36627
But I do have to say...it did take care of some of my upper lip lines. But the pain, itching and unsightliness wasn't really worth it. |
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Fri Apr 02, 2010 5:51 pm |
| Oh this does not sound like it's worth it at all! Beauty at any cost isn't my idea of a sane approach. Just my personal take. |
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I'LL SEE YOU ON THE DARKSIDE OF THE MOON.... |
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Fri Apr 02, 2010 9:04 pm |
My dad used this for a while. It's not for the faint of heart, but it's not much different than having a CO2 treatment to get rid of lip lines.
I wonder if one could use it a few days a week and still get the wound healing benefit? I am going to have to read up on this more. |
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No longer answering PM's due to numerous weird messages. |
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Fri Apr 02, 2010 9:50 pm |
| bethany wrote: |
My dad used this for a while. It's not for the faint of heart, but it's not much different than having a CO2 treatment to get rid of lip lines.
I wonder if one could use it a few days a week and still get the wound healing benefit? I am going to have to read up on this more. |
You are just so incredibly adventurous Lady! |
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I'LL SEE YOU ON THE DARKSIDE OF THE MOON.... |
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Sat Apr 03, 2010 2:15 am |
Apparently there was a study done proving that efudex would work for precancerous lesions when used only 2 days a week for an extended period of time. It was mentioned on a skin cancer forum
but I haven't read the study myself. |
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Sat Apr 03, 2010 7:29 am |
| lagomorph wrote: |
Apparently there was a study done proving that efudex would work for precancerous lesions when used only 2 days a week for an extended period of time. It was mentioned on a skin cancer forum
but I haven't read the study myself. |
I guess I am a bit of a chicken but using something this strong for wrinkles just frightens me to no end. |
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I'LL SEE YOU ON THE DARKSIDE OF THE MOON.... |
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Sat Apr 03, 2010 9:56 pm |
Here is an article on irritation vs. efficacy from 2004...see page 5 for the conclusion.
http://findarticles.com/p/articles/mi_m0PDG/is_1_3/ai_113650069/?tag=content;col1
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| AK represents the initial manifestation of a continuum of clinical, histologic, and molecular abnormalities that can progress to invasive SCC. Although topical fluorouracil is effective in treating AK, conventional formulations are associated with significant facial irritation that can lead to reduced compliance and limited efficacy. Various efforts have been made to reduce irritation side effects, including alteration of dosing schedules and use of combination therapies. A low-dose, microsphere-based formulation of 0.5% fluorouracil is now available, which appears to be associated with less facial irritation than conventional fluorouracil preparations, without sacrificing effectiveness. The combination of a low-dose formulation and microsphere-based drug-delivery technology may contribute toward improved efficacy, tolerability, and compliance in the large and growing number of patients with AK. |
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No longer answering PM's due to numerous weird messages. |
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Sat Apr 03, 2010 10:53 pm |
| Thanks bethany for the link, that is reassuring. You are such a bad influence, I love it! LOL |
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I'LL SEE YOU ON THE DARKSIDE OF THE MOON.... |
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Sun Apr 04, 2010 12:18 am |
| I've actually been using it ever since the first article was posted here. I hesitated to mention it because I didn't want to encourage anyone else. |
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Sun Apr 04, 2010 9:39 am |
Lagomorph-What have your results been? This is certainly a very personal decision to try it and you have been quite brave.
I am very curious what the side effects were for you, how long the recovery and what your outcome has been so far.
Thanks for stepping up and letting us know. |
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Joined the 50 club several years back, blonde w/ fair/sensitive skin, Texas humidity and prone to rosacea, light breakouts and sunburns, combo skin type, starting to see sundamage and fine lines |
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Sun Apr 04, 2010 12:17 pm |
| AnnieR wrote: |
Lagomorph-What have your results been? This is certainly a very personal decision to try it and you have been quite brave.
I am very curious what the side effects were for you, how long the recovery and what your outcome has been so far.
Thanks for stepping up and letting us know. |
Yes...please share!!! |
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No longer answering PM's due to numerous weird messages. |
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Sun Apr 04, 2010 12:48 pm |
| bethany wrote: |
| AnnieR wrote: |
Lagomorph-What have your results been? This is certainly a very personal decision to try it and you have been quite brave.
I am very curious what the side effects were for you, how long the recovery and what your outcome has been so far.
Thanks for stepping up and letting us know. |
Yes...please share!!! |
Ditto... please do tell!! |
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I'LL SEE YOU ON THE DARKSIDE OF THE MOON.... |
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Sun Apr 04, 2010 12:49 pm |
| bethany wrote: |
Here is an article on irritation vs. efficacy from 2004...see page 5 for the conclusion.
http://findarticles.com/p/articles/mi_m0PDG/is_1_3/ai_113650069/?tag=content;col1
| Quote: |
| AK represents the initial manifestation of a continuum of clinical, histologic, and molecular abnormalities that can progress to invasive SCC. Although topical fluorouracil is effective in treating AK, conventional formulations are associated with significant facial irritation that can lead to reduced compliance and limited efficacy. Various efforts have been made to reduce irritation side effects, including alteration of dosing schedules and use of combination therapies. A low-dose, microsphere-based formulation of 0.5% fluorouracil is now available, which appears to be associated with less facial irritation than conventional fluorouracil preparations, without sacrificing effectiveness. The combination of a low-dose formulation and microsphere-based drug-delivery technology may contribute toward improved efficacy, tolerability, and compliance in the large and growing number of patients with AK. |
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I looked over 2 web diaries of people who underwent this treatment, and I must say that there was a HUGE difference in the pics of the person that used the 5% vs. the .5% cream.
The 5% version:
http://www.sannerud.com/people/efudex/
The .5% version:
http://www.sannerud.com/people/efudex/My%20Carac%20Diary_files/frame.htm
But I have to tell you, I'm pretty sure I'm NOT signing up to trial this one!  If I ended up needing to have some skin cancer removed, I would do it...but until that day comes, I don't see it happening for me!
However, I recently removed an AK from my leg with the full strength hydrogen peroxide, and I may as well have done this...the pain, swelling, etc. has been pretty bad. I have serious doubts that it will ever look normal there again. |
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No longer answering PM's due to numerous weird messages. |
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Sun Apr 04, 2010 3:05 pm |
| DarkMoon wrote: |
| bethany wrote: |
| AnnieR wrote: |
Lagomorph-What have your results been? This is certainly a very personal decision to try it and you have been quite brave.
I am very curious what the side effects were for you, how long the recovery and what your outcome has been so far.
Thanks for stepping up and letting us know. |
Yes...please share!!! |
Ditto... please do tell!! |
Huge 3rd. What has it done for your skin!
I looked at the pictures from the links Bethany posted. Wow, as much as I want to diminish some wrinkles, I think this one is out of my league. |
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