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Fri Aug 27, 2010 1:17 am  |
Thank you for this post. I've followed the above links and I have to say that I am quite convinced! I'll keep eyes watching and ears listening.  |
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Fri Oct 15, 2010 5:24 pm |
I am by no means an expert, but thought it might be worth sharing. After my daughter was born, 12 yrs ago, I was really short on vitamins. One of the supplements that my DR told me to take was niacinamide. She told me to make sure that it was niacinamide and NOT niacin, because niacin would cause flushing.
I found some interesting links regarding the two:
Unfortunately I can't put the link in itself, because I'm too new to the forum, so I've split it up !!! There's always a way around these things 
- add in "http://www. to this ....
the mens-total-fitness.com/niacin-flush.html
and it will bring you to the link.
- add in http://www. to this .... smartskincare.com/treatments/topical/niacinamide.html
and it will bring you to the link. This site gave some useful information.
HTH |
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dvander
New Member
 
Joined: 13 Jul 2011
Posts: 1
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Wed Jul 13, 2011 5:09 pm |
I just joined this forum because of the niacinamide discussion (because of a bad reaction I had to a MAP serum used together with an Olay cream with niacinamide).
Thanks to everyone for all the great links. After reading through everything, there was sa key question that I had to find an answer to:
What dose of niacinamide leads to inhibition of SIRT1 activity?
It turns out that it takes quite a huge amount, probably more than we'd find in a 5% niacinamide cream, eg., 10 mM (millimolar) nicotinamide was used to treat individual kidney cells in this study: “Regulation of Translation and Transcription by SIRT 1: Potential Novel Mechanisms for Regulating Stress Response and Aging”
That's a HUGE concentration. Then in this 2006 study the authors said that, " 50 uM nicotinamide is well above the physiological levels of nicotinamide in mammalian organs" (search on: “Sirtuins, Nicotinamide and Aging: A Critical Review”)
So the first study mentioned used 1000 times more niacinamide that is considered "well above the physilogical levels" found in the human body. I wish I could find the concentration they used in this study: “T1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes” (but it seems they'd probably use similar amounts)
So far, it looks like niacinamide is probably safe and beneficial at the concentrations found in our skin care creams, but like anything, it can be dangerous in high doses.
eg., vitamin A is anti-aging but if I had too much of it I'd lose hair, get discolored skin, and have liver problems.
Also, if you’re already losing NADH and NADPH in your skin as you age, isn’t the addition of niacinamide going to restore your skin to a younger state, so you'd have an even longer way to overdose?
Please post more info if you have any. |
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Thu Jun 14, 2012 9:41 am |
Found this article stating that niacinamide is beneficial & in fact resveratrol is bad:
http://www.functionalps.com/blog/2012/03/20/ray-peat-phd-on-therapeutic-effect-of-niacinamide/
“In some of the publications claiming that resveratrol increases lifespan, it was reported that niacinamide had the opposite effect, suppressing Sir2, the longevity gene, and shortening the organism’s lifespan. To put their claims into context, it’s helpful to look at a variety of experiments involving treatment with niacinamide.
It protects nerves, vascular cells, insulin-producing cells in the pancreas, and a variety of other types of cell from cell death produced by lack of oxygen, excitotoxicity, endotoxin, and a variety of stressors and toxins. (Niacinamide acts in many ways as a negation of resveratrol; for example, resveratrol interferes with the ability of the beta cells to secrete insulin [Szkudelski, 2007]).
Niacinamide protects mitochondrial respiration from many of the age-related factors that can damage mitochondria and decrease energy production. Lipopolysaccharide, the bacterial endotoxin, increases the production of the free radical nitric oxide, leading to the secretion of inflammatory mediators and the suppression of energy production by the mitochondria. These effects are blocked by niacinamide (Fukuzawa, et al., 1997). Calorie restriction also protects mitochondrial respiration, in yeasts (Lin, et al., 2002) and rats (Broderick, et al., 2002)
The “replicative lifespan” of human cells in vitro is extended by treatment with niacinamide (Kang, et al., 2006).
In an experiment with human keratinocytes in vitro, resveratrol had the opposite effect, reducing their ability to divide (Blander, et al., 2009). By the definitions of “aging” used by the advocates of the rate-of-living theory, this experiment suggests that resveratrol causes premature aging. Estrogen has a similar effect on keratinocytes. Resveratrol, nitric oxide, and estrogen, unlike niacinamide, suppress mitochondrial respiration. Resveratrol inhibits the formation of progesterone (Chen, et al., 2007), which is synthesized in mitochondria.” |
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Thu Jun 14, 2012 10:12 am |
Where does trans-resveratrol fit in though? And grape seed extract?
| gretchen wrote: |
Found this article stating that niacinamide is beneficial & in fact resveratrol is bad:
http://www.functionalps.com/blog/2012/03/20/ray-peat-phd-on-therapeutic-effect-of-niacinamide/
�In some of the publications claiming that resveratrol increases lifespan, it was reported that niacinamide had the opposite effect, suppressing Sir2, the longevity gene, and shortening the organism�s lifespan. To put their claims into context, it�s helpful to look at a variety of experiments involving treatment with niacinamide.
It protects nerves, vascular cells, insulin-producing cells in the pancreas, and a variety of other types of cell from cell death produced by lack of oxygen, excitotoxicity, endotoxin, and a variety of stressors and toxins. (Niacinamide acts in many ways as a negation of resveratrol; for example, resveratrol interferes with the ability of the beta cells to secrete insulin [Szkudelski, 2007]).
Niacinamide protects mitochondrial respiration from many of the age-related factors that can damage mitochondria and decrease energy production. Lipopolysaccharide, the bacterial endotoxin, increases the production of the free radical nitric oxide, leading to the secretion of inflammatory mediators and the suppression of energy production by the mitochondria. These effects are blocked by niacinamide (Fukuzawa, et al., 1997). Calorie restriction also protects mitochondrial respiration, in yeasts (Lin, et al., 2002) and rats (Broderick, et al., 2002)
The �replicative lifespan� of human cells in vitro is extended by treatment with niacinamide (Kang, et al., 2006).
In an experiment with human keratinocytes in vitro, resveratrol had the opposite effect, reducing their ability to divide (Blander, et al., 2009). By the definitions of �aging� used by the advocates of the rate-of-living theory, this experiment suggests that resveratrol causes premature aging. Estrogen has a similar effect on keratinocytes. Resveratrol, nitric oxide, and estrogen, unlike niacinamide, suppress mitochondrial respiration. Resveratrol inhibits the formation of progesterone (Chen, et al., 2007), which is synthesized in mitochondria.� |
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_________________
Female, born 1985. HW Engineer, Fitness nut. Embarking on the war against the signs of aging... |
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Thu Jun 14, 2012 11:00 am |
| Well...I just saw Kassy say she drinks red wine and thinks it might have helped her also. |
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Thu Jun 14, 2012 11:28 am |
| egyptiangoddess wrote: |
| Well...I just saw Kassy say she drinks red wine and thinks it might have helped her also. |
LMAO That lady likes a bit of Merlot! |
_________________
I'LL SEE YOU ON THE DARKSIDE OF THE MOON.... |
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Thu Jun 14, 2012 11:40 am |
| I'm gonna pick up Total Effects Friday. |
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