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free skin care · Thu May 03, 2012 5:43 pm

jom wrote:

Wine could be a contributing factor to breast cancer. A breast cancer doc I know says women should only drink 1-2 glasses of any wine per week.

I was joking, I rarely drink at all! Laughing

Breastfeeding especially for extended periods has also been shown to reduce the risk of BC, than you have genetics and environmental factors ect. ect. ect.

free skin care · Thu May 03, 2012 5:49 pm

DrJ wrote:

Tiny wrote:

DrJ wrote:

Tiny wrote:

News just said that a new study said drinking red wine can "stop" cell aging!!! So I vote we call drink a few bottles while I read all this.

While the red wine theory has been around this is a new study.

Death also stops cell aging, but seems like the trade off is a bit severe.

sry Dr.J, you must of read this prior to my edit, the question was really about resveratol

It gets in, in the right vehicle. Its an antioxidant and anti-inflammatory. Not much more in skin.

https://www.jstage.jst.go.jp/article/bpb/31/5/31_5_955/_pdf

well it sounded hopeful

free skin care · Thu May 03, 2012 5:59 pm

Yay! Finally an *active* I can really get into.. Very Happy

Lush that I am... Laughing

free skin care · Thu May 03, 2012 6:12 pm

Kassy_A wrote:

Yay! Finally an *active* I can really get into.. Very Happy

Lush that I am... Laughing

Cheers!

free skin care · Thu May 03, 2012 6:17 pm

Well if it is the only way to get it

free skin care · Thu May 03, 2012 6:17 pm

LMAO! Now THAT'S a glass of vino! Cheer's

free skin care · Thu May 03, 2012 6:19 pm

Tiny wrote:

Well if it is the only way to get it

LMAO, You can buy it in supplements, but drinking some Red Wine sure would be more fun! Laughing

free skin care · Thu May 03, 2012 6:19 pm

DarkMoon wrote:

Tiny wrote:

Well if it is the only way to get it

LMAO, You can buy it in supplements, but drinking some Red Wine sure would be more fun! Laughing

shhhhhhhhhhhhhhhh

free skin care · Thu May 03, 2012 6:22 pm

Tiny wrote:

DarkMoon wrote:

Tiny wrote:

Well if it is the only way to get it

LMAO, You can buy it in supplements, but drinking some Red Wine sure would be more fun! Laughing

shhhhhhhhhhhhhhhh

OK......sorry i won't tell I promise! Now raise your glass you two! Cheers!

free skin care · Thu May 03, 2012 6:24 pm

Interesting about the Cabernet, I had heard it was Pinot Noir, since resveratrol is boosted due to that type of grape which is grown in colder climes.

BFG

free skin care · Thu May 03, 2012 6:26 pm

Barefootgirl wrote:

Interesting about the Cabernet, I had heard it was Pinot Noir, since resveratrol is boosted due to that type of grape which is grown in colder climes.

BFG

I am not sure why, but that is what the most recent studies show Cabernet has the highest polyphenol content!

free skin care · Thu May 03, 2012 6:43 pm

Antioxidants protect the cells and tissues in our bodies from damage. Red wines, such as cabernet and merlot, are high in antioxidants. Since these wines are made from different varieties of grapes, the types and levels of antioxidants between the two wines are not the same. If you enjoy drinking red wine, the American Heart Association recommends a daily limit of 4 ounces for women and 8 ounces for men.
IMPORTANT FACTORS
The amount of antioxidants in grapes is determined by the type of grape, geographic area and production method, according to MayoClinic.com. These factors affect the color of the wine produced. Generally, the darker the grape, the higher the antioxidant content. Wine made from red grapes tends to have more antioxidants than wine made from white or green grapes. Additionally, purple grapes are higher in antioxidants than red grapes.

TYPES OF GRAPES
Cabernet is made from the cabernet sauvignon grape variety. These grapes are dark red and purple with a thick skin. Merlot is made from grapes in the Gironde-Bordeaux wine-growing region. These grapes are red and thin-skinned, and ripen earlier than the Cabernet sauvignon variety. According to a 2011 study published in "Biotechnology & Biotechnology Equipment," the skin of the Cabernet sauvignon grapes have higher antioxidant content than the skin of the grapes used to make merlot.
PHENOLIC CONTENT
Polyphenols are antioxidant compounds in grapes that influence the color and taste of wine. In a 2009 study published in "Food Chemistry," researchers found a strong relationship between antioxidants and phenolic content. Red wines were higher in both antioxidants and phenolic content than white wines. Specifically, cabernet had the greatest number of antioxidants of the 37 wines studied.
RESVERATROL
Resveratrol is a type of antioxidant that plants produce to defend themselves from infection, injury and fungi. Grapes and red wine are high in resveratrol. Studies have found that resveratrol reduces the development of tumors and the spread of cancer cells, according to the National Cancer Institute. A 2003 study published by "Drugs Under Experimental and Clinical Research" compared levels of resveratrol in 19 red wines. Researchers found the highest concentration of resveratrol in merlot.

http://www.livestrong.com/article/556500-antioxidants-in-cabernet-vs-merlot/

Rotate your wine! Laughing

free skin care · Thu May 03, 2012 6:55 pm

DarkMoon wrote:

Rotate your wine! Laughing

free skin care · Fri May 04, 2012 3:59 pm

Tiny wrote:

DarkMoon wrote:

Rotate your wine! Laughing

OK, so wine is on the list. Is it time to come up with a top 10 best (and bottom 10 worst) ingredients?

free skin care · Fri May 04, 2012 4:45 pm

DrJ wrote:

Tiny wrote:

DarkMoon wrote:

Rotate your wine! Laughing

OK, so wine is on the list. Is it time to come up with a top 10 best (and bottom 10 worst) ingredients?

Ready and waiting! Laughing

free skin care · Fri May 04, 2012 6:05 pm

DrJ wrote:

Is it time to come up with a top 10 best (and bottom 10 worst) ingredients?

I'm guessing that your #1 best is BM-MSC and your #1 worst is renovage.

Here are some other ideas for best:
Vitamin A - all forms
Vitamin C (L-ascorbic acid)
Niacinamide
Vitamin E
Ferulic acid
coffeeberry
green tea
zinc oxide
soy isoflavones

And worst:
DMAE
Syn-Ake

free skin care · Fri May 04, 2012 7:41 pm

jom wrote:

DrJ wrote:

Is it time to come up with a top 10 best (and bottom 10 worst) ingredients?

I'm guessing that your #1 best is BM-MSC and your #1 worst is renovage.

Here are some other ideas for best:
Vitamin A - all forms
Vitamin C (L-ascorbic acid)
Niacinamide
Vitamin E
Ferulic acid
coffeeberry
green tea
zinc oxide
soy isoflavones

And worst:
DMAE
Syn-Ake

Ooh - I like your list. My comments ...

Vitamin A - all forms MOST FORMS
Vitamin C (L-ascorbic acid) LEFTY C
Niacinamide WORK HORSE
Vitamin E SOOTHING & SMOOTHING
Ferulic acid TOO SENSITIVE, & DOESN'T PLAY WELL WITH OTHERS - OK AS OFFICE PROCEDURE
coffeeberry YES
green tea EVEN BETTER
zinc oxide OF COURSE
soy isoflavones OH YEAH
UBUIQUINONE

And worst:
DMAE
Syn-Ake (SYNAKE OIL)
ARGIRILENE
TEPRENONE
UNBALANCED GROWTH FACTORS (egf)
ALL PEPTIDES FROM LIPOTEC

free skin care · Fri May 04, 2012 7:57 pm

DrJ wrote:

jom wrote:

DrJ wrote:

Is it time to come up with a top 10 best (and bottom 10 worst) ingredients?

I'm guessing that your #1 best is BM-MSC and your #1 worst is renovage.

Here are some other ideas for best:
Vitamin A - all forms
Vitamin C (L-ascorbic acid)
Niacinamide
Vitamin E
Ferulic acid
coffeeberry
green tea
zinc oxide
soy isoflavones

And worst:
DMAE
Syn-Ake

Ooh - I like your list. My comments ...

Vitamin A - all forms MOST FORMS
Which form(s) are not so good?

Vitamin C (L-ascorbic acid) LEFTY C
I'm a little slow sometimes what do you mean by that. I take it you don't think it's the best form of Vit. C. What type(s) do you think are most effective?

Niacinamide WORK HORSE

Vitamin E SOOTHING & SMOOTHING

Ferulic acid TOO SENSITIVE, & DOESN'T PLAY WELL WITH OTHERS - OK AS OFFICE PROCEDURE
Doesn't it play well with C & E, I thought Vit. C products were made better with ferulic acid?

coffeeberry YES
green tea EVEN BETTER
zinc oxide OF COURSE
soy isoflavones OH YEAH
UBUIQUINONE
We haven't talked about this before. What's so good about it? What does it do?

And worst:
DMAE
Syn-Ake (SYNAKE OIL)
ARGIRILENE
TEPRENONE
UNBALANCED GROWTH FACTORS (egf)
ALL PEPTIDES FROM LIPOTEC

Please see my comments/questions in italics and bold.

free skin care · Fri May 04, 2012 8:05 pm

coenzyme q10=ubiquinone I do believe we have discussed it as CoQ10 here with the doc.

free skin care · Fri May 04, 2012 8:09 pm

coenzyme Q10
Categories: Anti-Irritants, Antioxidants
Also known as ubiquinone, it is a vitamin-like, fat-soluble substance present in all human cells. It is responsible for cell protection and production of the body’s energy.

A handful of studies have shown that coenzyme Q10 (CoQ10) may have an effect on skin and the appearance of wrinkles, most notably by reducing UV damage, stimulating healthy collagen production, and reducing substances in damaged skin that wreck havoc on its support structure (Sources: Biofactors, Volume 32, 2008, pages 237–243; and November 2005, pages 179–185; Journal of Cosmetic Dermatology, March 2006, pages 30–38; andwww.naturaldatabase.com).

There is also research showing that sun exposure depletes the presence of CoQ10 in the skin. This is not surprising because many of the skin’s components become diminished on exposure to the sun. The latest research suggests that topical application of CoQ10 has antioxidant and anti-inflammatory effects. As such, it is one of many helpful antioxidants for skin, but it is not the only one or the “best” (Sources: Biofactors, September-October 2009, pages 435–441; Journal of Investigative Dermatology, 2005, volume 125, number 4, pages 12–13; and Journal of Dermatological Science, August 2001, Supplement, pages 1–4).

http://www.cosmeticscop.com/cosmetic-ingredient-dictionary/definition/393/coenzyme-q10.aspx

free skin care · Sat May 05, 2012 2:27 am

Biofactors. 2009 Sep-Oct;35(5):435-41.
Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells.
Muta-Takada K, Terada T, Yamanishi H, Ashida Y, Inomata S, Nishiyama T, Amano S.
Source

Shiseido Research Center, Yokohama, Japan. keiko.muta@to.shiseido.co.jp
Abstract

Coenzyme Q10 (CoQ10), which has both energizing and anti-oxidative effects, is also reported to have antiaging action, e.g., reducing the area of facial wrinkles. However, the mechanism of its anti-aging activity is not fully established. Here, we examined the effect of CoQ10 on human dermal and epidermal cells. CoQ10 promoted proliferation of fibroblasts but not keratinocytes. It also accelerated production of basement membrane components, i.e., laminin 332 and type IV and VII collagens, in keratinocytes and fibroblasts, respectively; however, it had no effect on type I collagen production in fibroblasts. CoQ10 also showed protective effects against cell death induced by several reactive oxygen species in keratinocytes, but only when its cellular absorption was enhanced by pretreatment of the cells with highly CoQ10-loaded serum. These results suggest that protection of epidermis against oxidative stress and enhancement of production of epidermal basement membrane components may be involved in the antiaging properties of CoQ10 in skin.

Copyright 2009 International Union of Biochemistry and Molecular Biology, Inc.

Biofactors. 2008;32(1-4):237-43.
Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo.
Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M, Ichihashi M.
Source

Tokiwa Pharmaceutical Campany Product Development, Japan.
Abstract

Photodamaged skin exhibits wrinkles, pigmented spots, dryness and tumors. Solar UV radiation induces cyclobutane pyrimidine dimers (CPD) and further produces base oxidation by reactive oxygen species (ROS). ROS are thought to be a major factor to initiate the up-regulation of matrix metalloproteinases (MMPs) in keratinocytes and fibroblasts via activation of receptor proteins on the cell membrane of keratinocytes and fibroblasts, and to degrade fiber components in dermis, leading to wrinkle formation. Coenzyme Q10 (CoQ10) was reported to reduce ROS production and DNA damage triggered by UVA irradiation in human keratinocytes in vitro. Further, CoQ10 was shown to reduce UVA-induced MMPs in cultured human dermal fibroblasts. We speculated that UVB radiation-induced cytokine production in keratinocytes may be inhibited by CoQ10, resulting in the reduction of MMPs in fibroblasts leading to wrinkle reduction. Our in vitro studies showed that UVB-induced IL-6 production of normal human keratinocyte (NHKC) decreased in the presence of CoQ10. Furthermore, MMP-1 production of fibroblasts cultured with the medium containing CoQ10 collected from UVB-irradiated NHKC significantly decreased during 24 h culture. In the clinical trial study, we found that the use of 1% CoQ10 cream for five months reduced wrinkle score grade observed by a dermatologist. Taken together, our results indicate that CoQ10 may inhibit the production of IL-6 which stimulate fibroblasts in dermis by paracrine manner to up-regulate MMPs production, and contribute to protecting dermal fiber components from degradation, leading to rejuvenation of wrinkled skin.

Carnosine?
L proline? <--- quencher of photoexcited states and all that ...good in SS. LED serums could probably use it too.
Identification of Quenchers of Photoexcited States as Novel Agents for Skin Photoprotection

Dermatol Surg. 2012 Jan;38(1):20-7. doi: 10.1111/j.1524-4725.2011.02158.x. Epub 2011 Sep 14.
Multiple pass ultrasound tightening of skin laxity of the lower face and neck.
Lee HS, Jang WS, Cha YJ, Choi YH, Tak Y, Hwang E, Kim BJ, Kim MN.
Source

Gowoonsesang Dermatologic Clinic, Seoul, Korea.
Abstract
BACKGROUND:

Skin laxity is a common complaint of patients who request skin rejuvenation. Radiofrequency and infrared light are widely used for nonablative treatment of skin laxity. Intense focused ultrasound (IFUS) has been investigated as a tool for the treatment of solid benign and malignant tumors for many decades but is only now beginning to emerge as a potential noninvasive alternative to conventional nonablative therapy.
OBJECTIVES:

To evaluate the efficacy of IFUS for the treatment of face and neck laxity.
METHODS:

Twelve female volunteers were enrolled in the study, and 10 were ultimately evaluated. The device under investigation was an IFUS. Areas treated included the face and neck. For treatment, the 4-MHz, 4.5-mm probe was used first, followed by the 7-MHz, 3.0-mm probe. Two blinded, experienced clinicians evaluated paired pretreatment and post-treatment (day 90) photographs. Patient self-assessments were also obtained.
RESULTS:

On the first primary outcome measure, two blinded clinicians felt that 8 of 10 subjects (80%) showed clinical improvement 90 days after treatment. Nine of 10 subjects (90%) reported subjective improvement.
CONCLUSIONS:

IFUS has many advantages for skin tightening.

Dermatol Surg. 2011 Nov;37(11):1595-602. doi: 10.1111/j.1524-4725.2011.02094.x. Epub 2011 Aug 1.
Intense focused ultrasound tightening in Asian skin: clinical and pathologic results.
Suh DH, Shin MK, Lee SJ, Rho JH, Lee MH, Kim NI, Song KY.
Source

Arumdaun Nara Dermatologic Clinic, Seoul, Korea.
Abstract
BACKGROUND:

Laxity and wrinkles of the aging face are common cosmetic concerns. Intense focused ultrasound (IFUS), a novel treatment modality for skin laxity, produces thermal effects at various depths while sparing overlying epidermis.
OBJECTIVE:

To evaluate the safety and efficacy of IFUS in facial skin tightening.
METHODS AND MATERIALS:

Twenty-two Korean patients with facial laxity were analyzed after a single IFUS treatment. Patient assessments were recorded, and two blinded, experienced clinicians who assessed improvement of nasolabial folds and jaw tightening evaluated photographs of patients and rated skin laxity. Skin biopsies were taken from 11 patients before and 2 months after treatment.
RESULTS:

Objectively, nasolabial folds and jaw lines were improved in all patients. Subjectively, 77% of patients reported much improvement of nasolabial folds, and 73% of patients reported much improvement at the jaw line. Histologic evaluation of skin biopsy samples using hematoxylin and eosin and Victoria blue stains showed greater dermal collagen with thickening of the dermis and straightening of elastic fibers in the reticular dermis after treatment.
CONCLUSION:

IFUS is a safe, effective, noninvasive procedure to tighten the facial skin of Asian patients. Improvement is associated with greater production of dermal collagen and straightening of dermal elastic fibers.

Do you think I'll blow the SLN's with the gadget?

You should see the Fe3SO4 jump around in the beaker with this thing blasting it. Just wanted to make sure it was actually doing anything.

free skin care · Sat May 05, 2012 7:59 am

DarkMoon wrote:

Barefootgirl wrote:

Interesting about the Cabernet, I had heard it was Pinot Noir, since resveratrol is boosted due to that type of grape which is grown in colder climes.

BFG

I am not sure why, but that is what the most recent studies show Cabernet has the highest polyphenol content!

I'm a fan of polyphenols, but my theoretical musings always bring me around to "how much is enough?" There is only so UVB-induced damage to DNA and matrix metalloproteinases induction and elastase stimulation to go around?

So ... cabernet vs ferrulic acid? or both?

free skin care · Sat May 05, 2012 8:03 am

DrJ wrote:

DarkMoon wrote:

Barefootgirl wrote:

Interesting about the Cabernet, I had heard it was Pinot Noir, since resveratrol is boosted due to that type of grape which is grown in colder climes.

BFG

I am not sure why, but that is what the most recent studies show Cabernet has the highest polyphenol content!

I'm a fan of polyphenols, but my theoretical musings always bring me around to "how much is enough?" There is only so UVB-induced damage to DNA and matrix metalloproteinases induction and elastase stimulation to go around?

So ... cabernet vs ferrulic acid? or both?

Drink the Cabernet and use the Ferulic acid in a serum?

We have a number of choices for topical polyphenols yes?

EGCG for one example.

Drink in moderation of course!

free skin care · Sat May 05, 2012 8:22 am

jom wrote:

DrJ wrote:

jom wrote:

DrJ wrote:

Is it time to come up with a top 10 best (and bottom 10 worst) ingredients?

I'm guessing that your #1 best is BM-MSC and your #1 worst is renovage.

Here are some other ideas for best:
Vitamin A - all forms
Vitamin C (L-ascorbic acid)
Niacinamide
Vitamin E
Ferulic acid
coffeeberry
green tea
zinc oxide
soy isoflavones

And worst:
DMAE
Syn-Ake

Ooh - I like your list. My comments ...

Vitamin C (L-ascorbic acid) LEFTY C
I'm a little slow sometimes what do you mean by that. I take it you don't think it's the best form of Vit. C. What type(s) do you think are most effective?

The d/l labeling is unrelated to (+)/(−); it does not indicate which enantiomer is dextrorotatory and which is levorotatory. Rather, it says that the compound's stereochemistry is related to that of the dextrorotatory or levorotatory enantiomer.

So, if Mr. Obama was a molecule, would he be levorotatory or dextrorotatory?

Ferulic acid TOO SENSITIVE, & DOESN'T PLAY WELL WITH OTHERS - OK AS OFFICE PROCEDURE
Doesn't it play well with C & E, I thought Vit. C products were made better with ferulic acid?

I refer to it being very heat labile and hard to mix with other chemicals (pH issues). That ferulic C+E you just ordered? By the time it sits in your mailbox in the sun for 20 minutes, most of the ferulic acid has degraded into something else. Gives it that nice smoky flavor though. Way too acidic for general formulation.

UBIQUINONE
We haven't talked about this before. What's so good about it? What does it do?

DragoN help.

And worst:
DMAE
Syn-Ake (SYNAKE OIL)
ARGIRILENE
TEPRENONE
UNBALANCED GROWTH FACTORS (egf)
ALL PEPTIDES FROM LIPOTEC

Please see my comments/questions in italics and bold.

free skin care · Sat May 05, 2012 9:46 am

DrJ wrote:

Ooh - I like your list. My comments ...

Vitamin A - all forms MOST FORMS
Vitamin C (L-ascorbic acid) LEFTY C
The d/l labeling is unrelated to (+)/(−); it does not indicate which enantiomer is dextrorotatory and which is levorotatory. Rather, it says that the compound's stereochemistry is related to that of the dextrorotatory or levorotatory enantiomer. This response is a little over my head and has me going - ??
Niacinamide WORK HORSE
Vitamin E SOOTHING & SMOOTHING
Ferulic acid TOO SENSITIVE, & DOESN'T PLAY WELL WITH OTHERS - OK AS OFFICE PROCEDURE
coffeeberry YES
green tea EVEN BETTER
zinc oxide OF COURSE
soy isoflavones OH YEAH
UBUIQUINONE

And worst:
DMAE I would like to know more about the placement of this one here.
Syn-Ake (SYNAKE OIL)
ARGIRILENE
TEPRENONE
UNBALANCED GROWTH FACTORS (egf)
ALL PEPTIDES FROM LIPOTEC

To add to this discussion DrJ - where would you place copper peptides? You seem to have some favorable comments on GHK-Cu on your blog.

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