Serum with Creatine
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free skin care · Tue Aug 21, 2012 12:10 pm

Hi,
I stumbled across this study and I foud it intriguing:

Quote:

Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects

http://onlinelibrary.wiley.com/doi/10.1111/j.1473-2165.2011.00579.x/abstract
I noticed many of the reputable skin care products have creatine listed somewhere in the ingredients.
Has anyone tried incorporating this in a DIY product? If yes, what raw material (creatine) did you use and where did you purchase it? I assume molecular mass / size matters...
Could you share a recipe that worked well?
I know the title states "male subjects" but the abstract seems a little more general. I wonder if it is hormone-dependent... in which case I'll have to ask my boyfriend to be a test subject as well..

Looking forward to hearing back from you!

free skin care · Tue Aug 21, 2012 12:12 pm

Here's a summary of the study:

Quote:

Summary:
Background: The dermal extracellular matrix provides stability and structure to the skin. With increasing age, however, its major component collagen is subject to degeneration, resulting in a gradual decline in skin elasticity and progression of wrinkle formation. Previous studies suggest that the reduction in cellular energy contributes to the diminished synthesis of cutaneous collagen during aging.

Aims: To investigate the potential of topically applied creatine to improve the clinical signs of skin aging by stimulating dermal collagen synthesis in vitro and in vivo.

Patients/Methods: Penetration experiments were performed with a pig skin ex vivo model. Effects of creatine on dermal collagen gene expression and procollagen synthesis were studied in vitro using cultured fibroblast-populated collagen gels. In a single-center, controlled study, 43 male Caucasians applied a face-care formulation containing creatine, guarana extract, and glycerol to determine its influence on facial topometric features.

Results: Cultured human dermal fibroblasts supplemented with creatine displayed a stimulation of collagen synthesis relative to untreated control cells both on the gene expression and at the protein level. In skin penetration experiments, topically applied creatine rapidly reached the dermis. In addition, topical in vivo application of a creatine-containing formulation for 6 weeks significantly reduced the sagging cheek intensity in the jowl area as compared to baseline. This result was confirmed by clinical live scoring, which also demonstrated a significant reduction in crow’s feet wrinkles and wrinkles under the eyes.

Conclusions: In summary, creatine represents a beneficial active ingredient for topical use in the prevention and treatment of human skin aging.

free skin care · Tue Aug 21, 2012 12:13 pm

Here's a summary of the study:

Quote:

Summary:
Background: The dermal extracellular matrix provides stability and structure to the skin. With increasing age, however, its major component collagen is subject to degeneration, resulting in a gradual decline in skin elasticity and progression of wrinkle formation. Previous studies suggest that the reduction in cellular energy contributes to the diminished synthesis of cutaneous collagen during aging.

Aims: To investigate the potential of topically applied creatine to improve the clinical signs of skin aging by stimulating dermal collagen synthesis in vitro and in vivo.

Patients/Methods: Penetration experiments were performed with a pig skin ex vivo model. Effects of creatine on dermal collagen gene expression and procollagen synthesis were studied in vitro using cultured fibroblast-populated collagen gels. In a single-center, controlled study, 43 male Caucasians applied a face-care formulation containing creatine, guarana extract, and glycerol to determine its influence on facial topometric features.

Results: Cultured human dermal fibroblasts supplemented with creatine displayed a stimulation of collagen synthesis relative to untreated control cells both on the gene expression and at the protein level. In skin penetration experiments, topically applied creatine rapidly reached the dermis. In addition, topical in vivo application of a creatine-containing formulation for 6 weeks significantly reduced the sagging cheek intensity in the jowl area as compared to baseline. This result was confirmed by clinical live scoring, which also demonstrated a significant reduction in crowï¿½s feet wrinkles and wrinkles under the eyes.

Conclusions: In summary, creatine represents a beneficial active ingredient for topical use in the prevention and treatment of human skin aging.

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