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Sun Sep 09, 2012 6:49 am  |
There is an article in today's Sunday Telegraph on research that is about to be undertken on stem cells taken from the patient's own blood, which is then purified and injected under the skin.
www.Sunday Telegraph/Science.co.uk |
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Sun Sep 09, 2012 7:35 am |
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For some, wrinkles are seen as a sign of character. For most, they are an unwelcome reminder of ageing.
However, scientists are developing a method that may finally end the need for the routine of treatments and moisturisers used to try to keep facial lines at bay.
The first clinical trials are to begin shortly on a treatment that uses stem cells purified from a patient’s blood to combat their own wrinkles.
The cells will be injected beneath the skin where they will grow into new skin cells to help restore the elasticity, claims Pharmacells, the Glasgow-based company behind the technology.
Athol Haas, the company’s chief executive, said: “The skin has a natural elastic property which comes from cells known as fibroblasts.
“The ability of the body to produce this elastic material slows down with age because the number of these fibroblasts decrease.
“By introducing large numbers of stem cells into the right place, we are increasing the ability of the body to produce this material. It is still in its early stages but we hope to begin phase one trials within the next 12 months.”
Until recently, anyone hoping to get rid of their wrinkles had to rely on cosmetic treatments that injected synthetic collagen under the skin as a filler to remove the lines.
Botox has now become popular for cosmetic treatments, where a neurotoxin from the bacteria Clostridium botulinum is injected to immobilise the muscles that can cause wrinkles.
Fibroblast cells produce collagen and help maintain the skin’s structural integrity.
Pharmacells, which will be conducting its first clinical trial with a clinic in Hong Kong, uses a technique to purify an unspecialised type of cell, known as blastocyst-like stem cells, which can develop into many different types of tissues in the body.
It will be the first therapy to use this type of cell and the company also hopes to develop new techniques to treat diseases such as heart disease and osteoarthritis.
Rajiv Grover, a plastic surgeon and president elect of the British Association of Aesthetic Plastic Surgeons, said it could be five to 10 years before stem cell treatments for wrinkles were widely available.
“It is an exciting prospect as the science of stem cells will influence plastic surgery and cosmetic medicine significantly in the future,” he said.
“There is some evidence stem cells, when injected, can improve skin quality, but until you have had studies that look at the long-term effect and the safety, you cannot be sure.” |
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No longer answering PM's due to numerous weird messages. |
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Sun Sep 09, 2012 9:19 am |
| bethany wrote: |
| Quote: |
Pharmacells, which will be conducting its first clinical trial with a clinic in Hong Kong, uses a technique to purify an unspecialised type of cell, known as blastocyst-like stem cells, which can develop into many different types of tissues in the body.
It will be the first therapy to use this type of cell and the company also hopes to develop new techniques to treat diseases such as heart disease[/b] |
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I think it is great that someone is doing an actual clinical trial. It say they are using blastocyst-like stem cell that can develop into many different types of tissues but don't both Lifeline and AA ( and maybe RL, I don't know) say that their pluripotent or MSC can turn into different kind of tissue also? I guess my question would be what makes blastocyst- like stem cell any better than what's already out there on the market? |
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Sun Sep 09, 2012 10:03 am |
| CookieD wrote: |
| I guess my question would be what makes blastocyst- like stem cell any better than what's already out there on the market? |
Yes, it would be great to know why they chose this type of stem cell to do the trials with.
Found this on wiki: In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells (these are called pluripotent cells), but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.
And this site gives definitions: http://stemcells.nih.gov/StemCells/Templates/StemCellContentPage.aspx?NRMODE=Published&NRNODEGUID={3C35BAB6-0FE6-4C4E-95F2-2CB61B58D96D}&NRORIGINALURL=%2finfo%2fglossary.asp&NRCACHEHINT=NoModifyGuest#blastocyst
Blastocyst—A preimplantation embryo of about 150 cells produced by cell division following fertilization. The blastocyst is a sphere made up of an outer layer of cells (the trophoblast), a fluid-filled cavity (the blastocoel), and a cluster of cells on the interior (the inner cell mass). |
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Sun Sep 09, 2012 10:06 am |
| CookieD wrote: |
I think it is great that someone is doing an actual clinical trial. It say they are using blastocyst-like stem cell that can develop into many different types of tissues but don't both Lifeline and AA ( and maybe RL, I don't know) say that their pluripotent or MSC can turn into different kind of tissue also? I guess my question would be what makes blastocyst- like stem cell any better than what's already out there on the market? |
This is an interesting overview:
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Embryonic stem cells have been derived from a variety of species, including humans, and are described as “pluripotent,” meaning that they can generate all the different types of cells in the body. Embryonic stem cells can be obtained from the blastocyst, a very early stage
of development that consists of a mostly hollow ball of approximately 150-200 cells and is barely visible to the naked eye. At this stage, there are no organs, not even blood, just an “inner cell mass” from which embryonic stem cells can be obtained.
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Other stem cell treatments, while promising, are still at very early experimental stages. For example, the mesenchymal stem cell, found throughout the body including in the bone marrow, can be directed to become bone, cartilage, fat and possibly even muscle. In certain experimental models, these cells also have some ability to modify immune functions. These abilities have created considerable interest in developing ways of using mesenchymal stem cells to treat a range of musculoskeletal abnormalities, cardiac disease and some immune abnormalities such as graft-versus-host disease following bone marrow transplant.
http://www.isscr.org/public/ISSCR08_PubEdBroch.pdf |
Notice that the MSC mention says nothing about skin. |
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Sun Sep 09, 2012 11:03 am |
But isn't this about actual cells, not about the cytokines or the lysated cells that are in the stem cell skin products?
The procedure described is more like a vampire face lift or a fat graft, but with stem cells instead of platelets or fat cells. |
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Sun Sep 09, 2012 12:00 pm |
| Lotusesther wrote: |
But isn't this about actual cells, not about the cytokines or the lysated cells that are in the stem cell skin products?
The procedure described is more like a vampire face lift or a fat graft, but with stem cells instead of platelets or fat cells. |
Correct. |
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No longer answering PM's due to numerous weird messages. |
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Mon Sep 10, 2012 3:49 am |
| I wouldn't be surprised if this is what some celebrities are already getting done. |
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Born 1950. There's a new cream on the market that gets rid of wrinkles - you smear it on the mirror!! |
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