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Thu Jan 12, 2006 7:14 am  |
I just started taking the supplement Carnosine.
I considered it for some time but just got around to looking at articles on MEDLINE.
The article that impressed me most was Hipliss, A.R., Brownson, C. and Carrier, M.J.
Mech. Aging Dev. 2001, sep 15 2001, vol 122(13) pages 1431-45.
In this article they examine the biochemical mechanisms that Carnosine rejuvanates fiberblasts both clutures and in vivo. This info suggests that Carnosine could make you healthier and repair wrinkles when taken internally (from other sources it is well absorbed). It also acts to prevent adverse effects from blood sugar spikes.
Carnosine is mainly found in red meat and some in poultry.
This article also suggests to me that it could be effective topically if it could be transported into the skin. It is water soluble which is a problem but it's molecular weight is 226 so it meets the rule of thumb that molecules under 500MW can generally be transported. Do the formulators have any ideas? |
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Mon Feb 19, 2007 3:22 am |
| Are you still taking this? How is it going? I've been reading a lot lately about this in regards to reducing glycotoxins and in skin health etc. In addition to only eating foods raw, steamed or boiled to prevent glycation I thought this would be a good supplement to take. Would love to hear from anyone taking it! Thanks! |
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Mon Feb 19, 2007 4:02 am |
From Skin Actives:
"Properties: accelerates and improves healing. Prevents cross-linking of collagen and other proteins in the dermis, one of the causes of wrinkles and loss of elasticity brought about by aging and exposure to UV (sunlight). Carnosine is also an antioxidant and seems to improve the immune response.
Use: in a gel, cream or lotion, a teaspoon per 4 oz. of base. "
http://skinactives.com/products/carnosine.htm
It is water-soluble and the suggested use is at a 5% concentration.
I have not tried this personally. |
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Mon Feb 19, 2007 5:05 am |
| Thanks for bumping this up. I need to reorder the oral Carnosine. It did help my lipid profiles and then I stopped taking it. I did order the powder from Skin ACtives. I just started using it. I can say that it does improve healing. I had red scratches on my arms that were not healing well (weeks)and I'd run out of my O2 serum this helped in days. I'll see longer term whether it helps with fine lines. I use so many things though it is hard to tell what is doing what and I do not change unless something is not going well. My skin is generally improving over time. |
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Thu May 14, 2009 8:19 am |
Just wondering if anyone has any tech info on using carnosine topically in DIY creams. I have the supplement in powder form. Have googled to no avail. Any help would be most appreciated  |
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Wed Sep 07, 2011 4:33 pm |
Carnosine can be costly and if you do research online you find that Beta-Alanine (much cheaper) taken orally will convert to Carnosine in the body.
You might get a tingling sensation when using it, so either lower the dose (or break dosing up and take intermitedly during the day). Or take with food.
I've got a TON of research which I've saved to Word Pad, as I wanted to be sure that Beta -Alanine does convert to carnosine in the body and also suggested dosages. 
Since Carnosine quenches cross linking etc you get lipfusion, which in and of itself is not harmful unless because of age or diet (or the initial phase of dosing with Beta Alanine causes elevation of lipofusion, DMAE will flush it out so the workings of your cells won't be hindered. so best to combine Carnosine or Beta Alanine with DMAE. |
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Sat Oct 08, 2011 5:11 pm |
| I just started taking Beta Alanine a few weeks ago with the hope of it helping my skin out. So far I havent noticed anything with my skin but I figure it will take several months to notice anything there, but what I have noticed is that I need less sleep and when I wake up I just wake up instead of feeling groggy for an hour or 2 and in general I seem to have more energy... all good |
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Thu Oct 13, 2011 3:18 am |
| patzy wrote: |
Carnosine can be costly and if you do research online you find that Beta-Alanine (much cheaper) taken orally will convert to Carnosine in the body.
You might get a tingling sensation when using it, so either lower the dose (or break dosing up and take intermitedly during the day). Or take with food.
I've got a TON of research which I've saved to Word Pad, as I wanted to be sure that Beta -Alanine does convert to carnosine in the body and also suggested dosages.
Since Carnosine quenches cross linking etc you get lipfusion, which in and of itself is not harmful unless because of age or diet (or the initial phase of dosing with Beta Alanine causes elevation of lipofusion, DMAE will flush it out so the workings of your cells won't be hindered. so best to combine Carnosine or Beta Alanine with DMAE. |
would be soooooooooooooooo very grateful if you'd consider posting some of the best links |
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Thu Oct 13, 2011 1:35 pm |
| Glamcat wrote: |
| I just started taking Beta Alanine a few weeks ago with the hope of it helping my skin out. So far I havent noticed anything with my skin but I figure it will take several months to notice anything there, but what I have noticed is that I need less sleep and when I wake up I just wake up instead of feeling groggy for an hour or 2 and in general I seem to have more energy... all good |
Yes, it also can keep those who are light sleepers awake, so take it earlier in the day, so you don't lose out on sleep.
Just remember that you need to be ingesting Histidine in combination with Beta Alanine so it will convert to Carnosine. (taking Carnosine straight, isn't the best method, due to the break down in the body, then the body having to remake it..go figure. So B.A.+Hisdine will convert and give you more Carnosine in the long run. I take a powdered Vegan supplement that has all the amino acids so of course, has Histidine in the same amount of Beta Alanine that I take. Perhaps I've mentioned this before, but take DMAE to clean up the lipofusion that is left behind in the body's cells during the use of Carnosone or the B.A.+Histadine use and conversion. Lipofusion in and of itself isn't bad, but over time can build up and hinder the proper functioning of cells, and we don't want that!
P.S. I have that 'jumping' of text when I try and post, can someone remind me how to correct that problem? |
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Thu Oct 13, 2011 1:55 pm |
| UmEnis wrote: |
| patzy wrote: |
Carnosine can be costly and if you do research online you find that Beta-Alanine (much cheaper) taken orally will convert to Carnosine in the body.
You might get a tingling sensation when using it, so either lower the dose (or break dosing up and take intermitedly during the day). Or take with food.
I've got a TON of research which I've saved to Word Pad, as I wanted to be sure that Beta -Alanine does convert to carnosine in the body and also suggested dosages.
Since Carnosine quenches cross linking etc you get lipfusion, which in and of itself is not harmful unless because of age or diet (or the initial phase of dosing with Beta Alanine causes elevation of lipofusion, DMAE will flush it out so the workings of your cells won't be hindered. so best to combine Carnosine or Beta Alanine with DMAE. |
would be soooooooooooooooo very grateful if you'd consider posting some of the best links |
I'll do my best, as I have a lot of research to wade through.
http://www.naturalskinrepair.com/l-carnosine.html
http://www.betaalanine.info/2006/12/21/thursdays-test/#more-24
to quote from the site directly above: Researchers have shown that when supplementing with beta-alanine for just 4 weeks, we can increase our carnosine concentration by 42-65%.
Unfortunately, only about 40% of the carnosine you take actually contains beta-alanine, making it an inefficient source at best. You are better off, from both efficiency and a financial standpoint, taking beta-alanine directly. You would have to take substantially more carnosine just to approach the increased concentrations of carnosine<!--[if !supportAnnotations]--> achieved by taking the scientifically recommended dose of beta-alanine. Clearly, taking beta-alanine is the superior solution to increasing carnosine levels.
Including this in case anyone falls into the catagories mentioned in the following quote: (I'm a Vegan thus my mentioning in previous posts regarding Hisdidine.)
This site mentions the diseases that carnosine can or may help: I know for a fact that the eye drops DO get rid of cataracts. This product has been on the market for years.
http://www.vrp.com/neuroendocrine-support/carnosine-multipurpose-anti-aging-nutrient-anti-aging-nutrient-review-and-update-part-5 |
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Thu Oct 13, 2011 2:52 pm |
| patzy wrote: |
| UmEnis wrote: |
| patzy wrote: |
Carnosine can be costly and if you do research online you find that Beta-Alanine (much cheaper) taken orally will convert to Carnosine in the body.
You might get a tingling sensation when using it, so either lower the dose (or break dosing up and take intermitedly during the day). Or take with food.
I've got a TON of research which I've saved to Word Pad, as I wanted to be sure that Beta -Alanine does convert to carnosine in the body and also suggested dosages.
Since Carnosine quenches cross linking etc you get lipfusion, which in and of itself is not harmful unless because of age or diet (or the initial phase of dosing with Beta Alanine causes elevation of lipofusion, DMAE will flush it out so the workings of your cells won't be hindered. so best to combine Carnosine or Beta Alanine with DMAE. |
would be soooooooooooooooo very grateful if you'd consider posting some of the best links |
I'll do my best, as I have a lot of research to wade through.
http://www.naturalskinrepair.com/l-carnosine.html
http://www.betaalanine.info/2006/12/21/thursdays-test/#more-24
to quote from the site directly above: Researchers have shown that when supplementing with beta-alanine for just 4 weeks, we can increase our carnosine concentration by 42-65%.
Unfortunately, only about 40% of the carnosine you take actually contains beta-alanine, making it an inefficient source at best. You are better off, from both efficiency and a financial standpoint, taking beta-alanine directly. You would have to take substantially more carnosine just to approach the increased concentrations of carnosine achieved by taking the scientifically recommended dose of beta-alanine. Clearly, taking beta-alanine is the superior solution to increasing carnosine levels.
Including this in case anyone falls into the catagories mentioned in the following quote: (I'm a Vegan thus my mentioning in previous posts regarding Histidine.)
This site mentions the diseases that carnosine can or may help: I know for a fact that the eye drops DO get rid of cataracts. This product has been on the market for years.
http://www.vrp.com/neuroendocrine-support/carnosine-multipurpose-anti-aging-nutrient-anti-aging-nutrient-review-and-update-part-5 |
OK PLEASE READ THIS POST AS THE ONE ABOVE HAS SOME CONFUSION (DUE TO MY POSTING AND EDITING INCORRECTLY.)
I'll do my best, as I have a lot of research to wade through.
http://www.naturalskinrepair.com/l-carnosine.html
http://www.betaalanine.info/2006/12/21/thursdays-test/#more-24
to quote from the site directly above: Researchers have shown that when supplementing with beta-alanine for just 4 weeks, we can increase our carnosine concentration by 42-65%.
Unfortunately, only about 40% of the carnosine you take actually contains beta-alanine, making it an inefficient source at best. You are better off, from both efficiency and a financial standpoint, taking beta-alanine directly. You would have to take substantially more carnosine just to approach the increased concentrations of carnosine achieved by taking the scientifically recommended dose of beta-alanine. Clearly, taking beta-alanine is the superior solution to increasing carnosine levels.
Including this in case anyone falls into the catagories mentioned in the following quote: Shouldn't I take extra histidine along with beta-alanine since histidine is a component of carnosine?
No, as histidine is already present in high concentrations in muscle, while beta-alanine is only present only in small amounts. Researchers have determined that it is beta-alanine that drives carnosine synthesis, not histidine. Since this has been proven repeatedly in research, there is no need to supplement with extra histidine to increase carnosine levels.
(I'm a Vegan thus my mentioning in previous posts regarding Histidine.)Vegans, vegetarians or the elderly,those that (don't eat large amounts of food or dieters *)that may not get enough histidine in their diets and are thus deficient, which may compromise optimal carnosine levels. It is suggested these communities bump up their protein intake to get enough histidine.
*I added the info within the parenthesis, as even if one is a carnivore, ones food intake may not be sufficient.
http://www.vrp.com/neuroendocrine-support/carnosine-multipurpose-anti-aging-nutrient-anti-aging-nutrient-review-and-update-part-5
This site mentions the diseases that carnosine can or may help: I know for a fact that the eye drops DO get rid of cataracts. This product has been on the market for years. |
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Thu Oct 13, 2011 3:47 pm |
Ahhhh yes, I'm taking Prolab Beta Alanine Extreme and it has Histidine added. I take it with food so that I dont get the flushing. One day last week I took it on an empty tummy and got the flushing - I freaked out a little bit as I had a fairly intense flushing episode a few years ago from Niacinamide.
I've been thinking I need to get some DMAE too - so I will look at that - so far I havent been able to find it here in the health food stores in Australia but I will resort to looking online/ebay. 
Yeah I hate that page jumping thing too - but I dont know how to stop it - I end up making a load of typos and instead of keep going I end up doing another post, lazy I know... what I should do is type my response in Word then cut and paste it but that just adds more time and sometimes I struggle to find the time to type the more lengthy or detailed posts anyway 
| patzy wrote: |
Yes, it also can keep those who are light sleepers awake, so take it earlier in the day, so you don't lose out on sleep.
Just remember that you need to be ingesting Histidine in combination with Beta Alanine so it will convert to Carnosine. (taking Carnosine straight, isn't the best method, due to the break down in the body, then the body having to remake it..go figure. So B.A.+Hisdine will convert and give you more Carnosine in the long run. I take a powdered Vegan supplement that has all the amino acids so of course, has Histidine in the same amount of Beta Alanine that I take. Perhaps I've mentioned this before, but take DMAE to clean up the lipofusion that is left behind in the body's cells during the use of Carnosone or the B.A.+Histadine use and conversion. Lipofusion in and of itself isn't bad, but over time can build up and hinder the proper functioning of cells, and we don't want that!
P.S. I have that 'jumping' of text when I try and post, can someone remind me how to correct that problem? |
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Thu Oct 13, 2011 6:46 pm |
| Glamcat wrote: |
Ahhhh yes, I'm taking Prolab Beta Alanine Extreme and it has Histidine added. I take it with food so that I dont get the flushing. One day last week I took it on an empty tummy and got the flushing - I freaked out a little bit as I had a fairly intense flushing episode a few years ago from Niacinamide.
I've been thinking I need to get some DMAE too - so I will look at that - so far I havent been able to find it here in the health food stores in Australia but I will resort to looking online/ebay.
Yeah I hate that page jumping thing too - but I dont know how to stop it - I end up making a load of typos and instead of keep going I end up doing another post, lazy I know... what I should do is type my response in Word then cut and paste it but that just adds more time and sometimes I struggle to find the time to type the more lengthy or detailed posts anyway
| patzy wrote: |
Yes, it also can keep those who are light sleepers awake, so take it earlier in the day, so you don't lose out on sleep.
Just remember that you need to be ingesting Histidine in combination with Beta Alanine so it will convert to Carnosine. (taking Carnosine straight, isn't the best method, due to the break down in the body, then the body having to remake it..go figure. So B.A.+Hisdine will convert and give you more Carnosine in the long run. I take a powdered Vegan supplement that has all the amino acids so of course, has Histidine in the same amount of Beta Alanine that I take. Perhaps I've mentioned this before, but take DMAE to clean up the lipofusion that is left behind in the body's cells during the use of Carnosone or the B.A.+Histadine use and conversion. Lipofusion in and of itself isn't bad, but over time can build up and hinder the proper functioning of cells, and we don't want that!
P.S. I have that 'jumping' of text when I try and post, can someone remind me how to correct that problem? |
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Yep I spent almost 2 hours working on my last post, mostly due to the jumping.
Try COQ 10 or Alpha Lipic Acid, curcumin, DMAE (if you can find it). To combat lipofusion. I would think Vitamin C would help as we can see when we use it or Vit C containing lemon juice on a cut apple or bananas (among other things) it stops the 'browning' effect.
A lengthy but interesting article/s on lipofusion:
http://www.vincegiuliano.name/Antiagingfirewalls.htm#OxidativeDamagetoTissuesFirewall |
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Thu Oct 13, 2011 11:47 pm |
Thanks so much Patzy Yes, do I take Q10 and Alpha Lipoic Acid, Lecithin (choline) - and I found a local health supplements seller on ebay and ordered some Source Naturals DMAE so that should arrive on Monday... I really appreciate your input
Have you experienced the flushing from Beta Alanine? I was a little concerned when it happened! lol |
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Fri Oct 14, 2011 12:24 pm |
| Glamcat wrote: |
Thanks so much Patzy Yes, do I take Q10 and Alpha Lipoic Acid, Lecithin (choline) - and I found a local health supplements seller on ebay and ordered some Source Naturals DMAE so that should arrive on Monday... I really appreciate your input
Have you experienced the flushing from Beta Alanine? I was a little concerned when it happened! lol |
You are more than welcome. Glad I could help.
Great! You are using some good anti-lipofusion supplements.
No I never experienced the flushing, but then I mix in Beta Alanine with my Protein/Amino acid powder that I take daily to make sure I get the proper amount of protein and of course the Histidine to combine with the Beta Alanine.
I'm tempted to try it alone to see if I get the flushing. Is it bad?  lol. |
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Fri Oct 14, 2011 4:04 pm |
The flushing from the Beta Alanine wasnt bad but it took me by surprise! lol It started in my hands, they got all warm and itchy, and kinda tingly, then it moved to my elbows and shoulders and went down my back a bit - it lasted in the hands the longest then with each section it progressed to it stayed there for about 5 minutes.
It made me concerned enough to come to my computer and google "Beta Alanine side effects" lol and I discovered it was normal and that it will eventually stop doing it once your body adjusts to taking the supplements, or the other way is to reduce the dosage taking smaller dosages throughout the day.
I suppose it only concerned me so much because I did one time have a severe flushing. I had ran out of my Niacin supplements so I went to the local chemist, he was out of the supplement too so he sold me a bottle of Nicotinamide - which I might add, I later found out that he was not supposed to as it is strictly an OTC product for people with high blood pressure. Anyway I took the Nicotinamide the following morning with the rest of my supps with breakfast then within about 20 minutes I had a severe flushing which caused me to black-out, it was really scary, my body became really hot and my heart was racing, I looked in the mirror and I looked as though I'd been severely sunburnt that's how red I was - I was having trouble breathing, my whole body was itching and I had this intense tinglling. It was a Saturday and my husband was working but I had to phone him because I thought I was going to die (and our daughter was only 3 at the time - I didnt want her left alone if I died) and I've never thought that ever before and he raced home and found me passed out in the shower. I'd turned the cold water on to try to cool down as I was burning up.
I told him all I'd had different was the Nicotinamide, so he phoned the chemist and asked if it could do that and he said YES! The chemist told me to see my doctor asap and when I saw my doctor we went mental saying it could have killed me - he said it's strictly for high blood pressure (and I suffer from LOW blood pressure!). My doc said the heart racing/palpitations could have caused me to have a cardiac arrest. There's a bit more to it but I dont want to bore you! lol
So yeah when I got that sensation from the Beta Alanine I panicked! hahaha... but it was really mild by comparison! |
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Fri Oct 14, 2011 7:22 pm |
| Glamcat wrote: |
The flushing from the Beta Alanine wasnt bad but it took me by surprise! lol It started in my hands, they got all warm and itchy, and kinda tingly, then it moved to my elbows and shoulders and went down my back a bit - it lasted in the hands the longest then with each section it progressed to it stayed there for about 5 minutes.
It made me concerned enough to come to my computer and google "Beta Alanine side effects" lol and I discovered it was normal and that it will eventually stop doing it once your body adjusts to taking the supplements, or the other way is to reduce the dosage taking smaller dosages throughout the day.
I suppose it only concerned me so much because I did one time have a severe flushing. I had ran out of my Niacin supplements so I went to the local chemist, he was out of the supplement too so he sold me a bottle of Nicotinamide - which I might add, I later found out that he was not supposed to as it is strictly an OTC product for people with high blood pressure. Anyway I took the Nicotinamide the following morning with the rest of my supps with breakfast then within about 20 minutes I had a severe flushing which caused me to black-out, it was really scary, my body became really hot and my heart was racing, I looked in the mirror and I looked as though I'd been severely sunburnt that's how red I was - I was having trouble breathing, my whole body was itching and I had this intense tinglling. It was a Saturday and my husband was working but I had to phone him because I thought I was going to die (and our daughter was only 3 at the time - I didnt want her left alone if I died) and I've never thought that ever before and he raced home and found me passed out in the shower. I'd turned the cold water on to try to cool down as I was burning up.
I told him all I'd had different was the Nicotinamide, so he phoned the chemist and asked if it could do that and he said YES! The chemist told me to see my doctor asap and when I saw my doctor we went mental saying it could have killed me - he said it's strictly for high blood pressure (and I suffer from LOW blood pressure!). My doc said the heart racing/palpitations could have caused me to have a cardiac arrest. There's a bit more to it but I dont want to bore you! lol
So yeah when I got that sensation from the Beta Alanine I panicked! hahaha... but it was really mild by comparison! |
Wow! Now I understand why the BA flush/itch freaked you. You should have reported your chemist. (British?) Well, you kept your head and thought to call and lucky, since you had passed out. 
Yes the itching and flushing is called parathesia.
At first when I was researching BA I read about a side effect (parathesia) and thought, oh no, I find a great supplement and there is some terrible neurological side effect. (and I'm a nurse, but I had no clue as to what it was) Was happy to learn what it actually was.
May I ask, how much BA do you take daily? I've been taking 1 gram. Some sites say higher, tho the research I have said at the most 1500 mg. a day. I stumbled across teprenone which has been found to be great for 'reversing' aging, but for now it is prescribed for gastric ulcers, but it doesn't hurt the gastric mucosa. One can get it for topical use, but not as an oral supplement. Tho' I imagine some doctors are taking it already for it's benefits. 
Ah well, we will have to all depend on Carnosine or our Beta Alanine and Alpha Lipoic Acid for now. |
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Sat Oct 15, 2011 2:24 am |
I'm in Australia - so yes we call them chemists/pharmacists- the person or chemists/pharmacies- the store lol
Yes, my husband certainly went off-tap at the pharmacist when he phoned him to ask if it was a usual reaction to the Nicotinamide. I phoned the manufacturer of the product a few days later and they reported the pharmacist for selling me the product when my blood pressure is low and my triglycerides are perfect.
I actually say that to my doctor - that I think doctors get inside knowledge on how to stay healthier and younger looking than the rest of us! lol My doctor is in his 50's and he looks darn good! lol He assures me there are no insider secrets reserved for doctors but I'm not so sure!
Most days with the BA I'm taking 1000 - 1500mg - the bottle I have says you can take up to 4000mg a day! |
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Sun Oct 16, 2011 7:20 pm |
| Glamcat wrote: |
I'm in Australia - so yes we call them chemists/pharmacists- the person or chemists/pharmacies- the store lol
Yes, my husband certainly went off-tap at the pharmacist when he phoned him to ask if it was a usual reaction to the Nicotinamide. I phoned the manufacturer of the product a few days later and they reported the pharmacist for selling me the product when my blood pressure is low and my triglycerides are perfect.
I actually say that to my doctor - that I think doctors get inside knowledge on how to stay healthier and younger looking than the rest of us! lol My doctor is in his 50's and he looks darn good! lol He assures me there are no insider secrets reserved for doctors but I'm not so sure!
Most days with the BA I'm taking 1000 - 1500mg - the bottle I have says you can take up to 4000mg a day! |
I think I'll stick with between 1000 mg and 1500mg for now. I'll let others be the guinea pigs! |
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Wed Nov 02, 2011 5:41 pm |
Whoa! I upped my doseage to two rounded 1/4 tsp. which according to the bottle equals about 2 grams and I got a prickling sensation, especially on my arms. Seems to raise internal temp. I guess I should take temp. before and after ingesting.
I took it with my powdered Vegan protein drink, so was surprised I got the parathesia effect.
The protein drink has histidine in it but doesn't equal my intake of Beta Alanine. I'm thinking I'll have to supplement to match the amount and thus, get the creation of Carnosine. One article said for Vegans and vegetarians and those whose diets are marginal, to just up their protein intake. I guess if I get 50grams a day I'll be ok.  |
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Thu Nov 03, 2011 12:06 am |
| Whoa! Patzy! I hope you're ok - it passes in about 30 minutes, but it sure is freaky when it happens! |
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