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free skin care · Wed Nov 09, 2011 7:36 am

Sunscreen is very important, I agree. Your skin can try all it can to repair existing damage, it's an uphill battle if new damage is done every day.
I don't use retin-a because from what I read it's very agressive. I do use retinyl acetate, and am happy with the results.

free skin care · Wed Nov 09, 2011 11:50 am

Barefootgirl wrote:

Hi gretchen,

Do you have more information on clinical studies behind:

- *Renovage
- *LED light therapy
- *facial exercises
- *intermittent fasting

All links, references, data - much appreciated!!

BFG

I'm not great with the Pub Med medical research thing but there are a lot of other people who've written aritcles who cite medical refrences. Intermittent fasting is just all around *healthy*; anything that is healthy is bound to make you look younger.

http://www.maxworkouts.com/blog/comments/is-intermittent-fasting-the-real-thing-or-just-another-gimmick/

http://www.sunwarrior.com/blog/weight-loss/intermittent-fasting-getting-younger-every-day

http://www.theiflife.com/advantages-intermittent-fasting-feeding/

http://www.theiflife.com/the-longevity-gene-sirt1-part-i-cr-fasting-and-aging-diseases/

As for clinical studies on facial exercises ?? There's the Flex Effect website/crowd-- lots of befores and afters, often impressive.
http://www.flexeffect.com/research.htm

Renovage is mostly word-of-mouth online. I believe teprenone is very promising.
Here's an article from Garden of Wisdom:
http://www.gardenofwisdom.com/renovage.html

LED light was originally researched/developed by NASA:
http://www.light4beauty.com/

I personally use the Tua Trend. There are no clinical trials on that that I know of, just Kate Moss.

free skin care · Wed Nov 09, 2011 12:26 pm

I read the term 'intermittent fasting' on this forum quite a lot. What exactly does it mean? Do you mean by that that you fast one day a week? Or that you don't eat during the main part of the day and take one major meal in the evening?

free skin care · Wed Nov 09, 2011 12:35 pm

Lotusesther wrote:

I read the term 'intermittent fasting' on this forum quite a lot. What exactly does it mean? Do you mean by that that you fast one day a week? Or that you don't eat during the main part of the day and take one major meal in the evening?

There's a lot of systems online; ie, Eat Stop Eat, Fast 5, The Warrior Diet, Every Other Day diet etc. To get the benefits you have to fast 15-19 hours which amounts to skipping one meal per day. The benefits drop off after about 36 hours etc.

free skin care · Wed Nov 09, 2011 7:01 pm

With respect to collagen building, the only topicals, etc. that I am aware of, that are backed by science are:

retinoids
certain vitamin formulations
certain hormone treatments

possible procedures such as professional lasers and peels.

bfg

free skin care · Wed Nov 09, 2011 9:01 pm

free skin care · Thu Nov 10, 2011 1:40 am

Glycolic and Retinoid are good to keep cell renewal. But, I think there's always a limit
on even very high end products.

free skin care · Sun Nov 20, 2011 9:48 am

rileygirl wrote:

cm5597 wrote:

This is a very good point, and I take your point. It is a weakness of some of the articles I posted and much/most of the articles on aloe. I guess the things are more compelling to me are the alleviation of inflammation (which we all have to some degree), the seemingly beneficial effects on collagen in general, and the decrease in wrinkles in that oral supplementation study.

Yes, agree, we do all have some form of inflammation. I am interested in the oral supplementation and will definitely look into that. Do you take aloe vera internally, CM?

No, I don't. But I don't have any particular reasoning either way...just have not given that possibility much attention or thought.

free skin care · Sun Nov 20, 2011 9:59 am

Lacy53 wrote:

I don't like mouse studies either; nor do I like studies which involve a small number of subjects.

Tell me about it! Both of these rank highly among my frustrations.

cm5597 wrote:

However, I do think you have to consider the source of a study and in this case it is the National Toxicology Program, Department of Health and Human Services. I am not American, but I am assuming they conduct quality research and their findings are respected in the scientific community.

With respect to taking aloe internally, the NTP is wrapping up a 2 year study on this topic (using rats and mice). Although I couldn't find the finalized report, you can read a preliminary abstract here:

http://ntp.niehs.nih.gov/?objectid=4DC2C23C-F1F6-975E-7F58092819E2C69F

Thanks for passing this along, Lacy53, and for putting safety on our radar. I will definitely try to watch this space more closely now that you have alerted us to it.

However, the one thing about this study is that the neoplastic lesions were observed in rodents consuming the whole-leaf aloe.

In my book, this is a major flaw because whole-leaf aloe is known to cause diarrhea and intestinal distress, so it is no surprise to me that it caused negative effects (in this case, hyperplasia) in the colon.

It's too bad that they didn't consider this when designing their research study, since we consume and use the gel, not the whole leaf which contains the intestinal irritants.

Why they didn't design this study to mimic how aloe is actually used (stripped of the digestive irritants) baffles me. That would have been a lot more useful.

free skin care · Sun Nov 20, 2011 10:03 am

rileygirl wrote:

Lacy53 wrote:

With respect to taking aloe internally, the NTP is wrapping up a 2 year study on this topic (using rats and mice). Although I couldn't find the finalized report, you can read a preliminary abstract here:

http://ntp.niehs.nih.gov/?objectid=4DC2C23C-F1F6-975E-7F58092819E2C69F

Thanks for the link, Lacy. This is the summary at the end of that article:

"Under the conditions of these 2-year drinking water studies, there was clear evidence of carcinogenic activity of a nondecolorized whole leaf extract of Aloe vera in male and female F344/N rats based upon increased incidences of adenomas and carcinomas of the large intestine. There was no evidence of carcinogenic activity in male or female B6C3F1 mice exposed to 1.0%, 2.0%, or 3.0 % (wt/wt) Aloe vera whole leaf extract in drinking water.

Exposure to a nondecolorized whole leaf extract of Aloe vera resulted in increased incidences of nonneoplastic lesions of the large intestine in male and female rats and mice, the small intestine of male and female rats, the stomach in male and female rats and female mice, the mesenteric lymph nodes in male and female rats and male mice, and the nose in male mice."

Interesting. So they found negative results with the whole leaf aloe in one type of rats, but not in another type of rats. This is just a reminder of how difficult it can be to extrapolate animal studies to humans (though they can be useful).

free skin care · Sun Nov 20, 2011 10:12 am

Barefootgirl wrote:

Hi gretchen,

Do you have more information on clinical studies behind:

- *Renovage
- *LED light therapy
- *facial exercises
- *intermittent fasting

All links, references, data - much appreciated!!

BFG

Hey BFG,

In the back of the book on "Fast Five" (one of the many approaches to intermittent fasting), Dr. Herring lists references to medical studies. You can get a copy of his book for free if you go to the Fast-5 website and email him.

I do recall that I heard that there was some NIH study when the volunteers only ate in a 4 hour window...but I have not looked up studies on it on PubMed, so this is hearsay.

FWIW, I, too, have been experimenting with intermittent fasting done the Fast-5 way and am really digging it! And I keep my calorie intake the same, so the effects for me personally are not from cutting calories.

HTH Smile

free skin care · Sun Nov 20, 2011 11:15 am

In addition to sunscreen, I would suggest using Vitamin C products in the morning and Retinol in the evening, plus facial exercise.

free skin care · Tue Oct 28, 2025 10:04 am

For a 58-year-old focusing on evidence-based skincare, stick with a simple routine: a gentle cleanser, a Vitamin C serum in the morning, Retin-A (tretinoin) at night, a good moisturizer, and broad-spectrum SPF 30+ sunscreen daily. Ingredients with strong research backing include retinoids, Vitamin C, peptides, hyaluronic acid, and ceramides. You can also check https://crepe-erase.pissedconsumer.com/customer-service.html for additional information or reviews on specific products. Focus on consistency, and choose products that contain these proven ingredients rather than chasing trends or claims.

Tue Nov 04, 2025 2:48 am

Great discussion, thanks for all the honesty about how your skin responds to tretinoin. I’ve found that consistent use plus a reliable source for getting the product makes a big difference in staying on track rather than dropping off because of irritation or confusion. If anyone’s looking for a trusted option, I regularly buy tretinoin from Tretinoin Store Australia , their site lists product details and shipping info for Australian customers.
Also: remember that starting slow (every other night) and giving skin time to adjust can really help-reduce the “dry mess” phase others mention. Hope this helps!

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