ISCO Stem Cell: Lifeline Skin Care: general discussion
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free skin care · Sat Nov 27, 2010 4:19 pm

Frodo wrote:

Well, not surprised about the prices. Day product is $155 and evening product is $185. Now, from a company that has been working on this for quite sometime and probably spent a fortune bringing it to market you would think they could get the directions right on the website. Day cream says to use at night.

They fixed it, wonder if they are reading the forums?

If you are reading the forums how about dropping the prices. Very Happy

On second thought since I posted their error they should send me the products free. Wink

I'm waiting for a PM asking me for my name and mailing address.

Please excuse my silliness ladies, I am in such a funny mood today. I haven't been sleeping much lately so I am way off kilter.

free skin care · Tue Nov 30, 2010 2:29 am

After I get done testing the products that I have on order I think that I may try this.
I used to use ISCO products when I was culturing cells in the lab. ISCO, as a company, has done extensive research for cell growth media and supplements for many types of cells. And they've been around for over 20 years.

It can probably be assumed that the actives were thoroughly tested using different types of human skin cells using cell culturing methods. If the actives actually permeate the skin deep enough and remain active this could very well be a breakthrough in skin care science.

The Osmosis StemFactor may very well work also but I don't know much about the company. Cell culture products is what ISCO does.

I just sent them an email requesting that samples be sold and that they list the ingredients. Perhaps if a lot of us requested small sample bottles be sold for evaluation purposes they would comply.

free skin care · Tue Nov 30, 2010 2:37 am

bushy wrote:

I have been following this company for a while, waiting for them to release their products. I received an email a couple of weeks ago with an offer to purchase before the end of November with $40 off. I wanted to take it up but was told no overseas shipping at this stage. I was hoping that would change soon but from what Keliu has said, it may not be too soon. There used to be a company called Shop the States which had reasonable prices to purchase in the US and have it sent to Australia but they went out of business and I don't know of another which has reasonable rates.

Try shipito.com, bushy. I've used them several times to ship from the US to the UK.

free skin care · Wed Dec 01, 2010 3:59 pm

Where are these Shareholders' reviews available to read?

free skin care · Fri Dec 03, 2010 12:31 pm

The ingredients in the LifeLine Skincare products are:

December 2010

Day Serum

Active ingredients: Avobenzone 3%, Oxtinoxate 7.4%, Oxybenzone 3%.
Inactive ingredients: Aqua (Water), Stearic Acid, Ubiquinone, Pluripotent Non-Embryonic Stem Cell
Extract, Glyceryl Stearate SE, Cetyl Alcohol, C12-15 Alkyl Benzoate, Troxerutin, Choline Chloride, DCalcium
Pantothenate, Folic Acid, Nicotinamide, Pyridoxal Hydrochloride, Riboflavin, Thiamine
Hydrochloride, i-Inositol, Sodium Chloride, Glycerin, Tremella Funciformis Sporocarp Extract, Sodium
PCA, Isoquercetin, Vaccinium, Angustilolium (Blueberry) Fruit Extract, Retinyl Palmitate, Tocopherol,
Sodium Ascorbyl Phosphate, Cholecalciferol, Polysorbate 60, Phenoxyethanol, Polysorbate 20, Sorbitan
Sesquiolate, Ethylhexyl Glycerin, Caprylyl Glycol, Propylene Glycol, Hexylene Glycol, Disodium
EDTA, Carbomer, Triethanolamine.

Night Serum

Ingredients: Aqua (Water), Caprylic/Capric Triglyceride, Pluripotent Non-Embryonic Stem Cell Extract,
Stearic Acid, Glyceryl Stearate SE, Ubiquinone, Carthamus Tinctorius (Safflower) Seed Oil, Cetyl
Alcohol, Troxerutin, Choline Chloride, D-Calcium Pantothenate, Folic Acid, Nicotinamide, Pyridoxal
Hydrochloride, Riboflavin, Thiamine Hydrochloride, i-Inositol, Sodium Chloride, Glycerin, Tocopheryl
Acetate, Retinyl Palmitate, Tremella Funciformis Sporocarp Extract, Isoquercetin, Vaccinium
Angustilolium (Blueberry) Fruit Extract, Camellia Oleifera Leaf Extract, Sodium PCA, Polysorbate 60,
Phenoxyethanol, Polysorbate 20, Sorbitan Sesquiolate, Ethylhexyl Glycerin, Caprylyl Glycol, Carbomer,
Propylene Glycol, Hexylene Glycol, Disodium EDTA, Triethanolamine.

free skin care · Sun Mar 20, 2011 1:53 am

Darkmoon, there is a huge difference between the companies that produce Stemulation and Lifeline Skincare.
I have to say that I was slightly turned off Stemulation after I saw the awful photos on Facebook before they were removed. It didn't seem like a very professional outfit.
On the other hand, ISCO which produces Lifeline Skincare has a lot of research behind it in stem cell technology and of all the skincare containing a form of stem cells, this company seems to have the most promising products imo.

Wed Feb 01, 2012 2:33 pm

softcare wrote:

Hi,

Can anybody tell me why pluripotent stem cells would be any better that any other stem cell when it comes to skin? I thought it was only the stuff they make in lab culture anyway. I've read about cytokines, growth factors, etc. All stem cells seem to make these.

Thanks

You’re right, softcare. There are some similarities between growth factors—the difference is in the potency, the stability, the delivery system, and the ability of the growth factors, peptides, etc. to stimulate gene expression (collagen, elastin, etc.)

This is what our stem cell scientists love to talk about, but let me try to distill into language that mere mortals can understand.

There are basically several different kinds of stem cells used in skincare products—human pluripotent stem cells, adult somatic stem cells and plant stem cells.

Human pluripotent stem cells (Lifeline).
Source: Created from unfertilized oocytes (female eggs, which have been donated from IVF clinics). These pluripotent stem cells have the capacity to differentiate into any one of 220 different cell types found in the human body (become bones, muscle, lungs, etc.) but have not yet done so. They are more potent than any other kind of stem cell because they are much closer to the original oocyte. Each time the stem cells divide they become more specialized, but also weaker.
The benefits: cellular proliferation, gene regulation and DNA repair
Preservative: Lipid bi-layer nanosphere
Potency: High

Adult stem cells
Source: Discarded tissue (for example, from circumcision or from abdominoplasty)
Benefits: Gene regulation, collagen synthesis.
Preservative: Usually parabens
Potency: The fibroblast growth factors are derived from skin cells, so they are several generations away from the pluripotent stem cell. Consider a photocopy. Each time the image is reproduced, it loses quality and resolution. The potency varies depending on the preservative used. Unless the growth factors are stabilized and can penetrate the skin, they have limited value.

Plant stem cells
Source: Apples, melons, rice
Benefits: anti-oxidants

There are also some companies that offer products with growth factors that are not derived from any living thing—they’re completely synthetic. So as you can see, not all growth factors are created equal.

Wed Feb 01, 2012 7:45 pm

Thanks. Good summary.

What I read is that the difference between pluripotency between these different stem cells is not significant to how well they work. That the important thing is the natural function of the type of stem cell in the body. Certain stem cells in the body specialize in repair and regeneration, and are the same ones responding to strokes, heart attacks. They specialize in healing and regeneration, while embyronic stem cells biologic function is to grow and differentiate into whole humans, not respond to damage. Different sets of cytokines involved. It makes sense to me that the repair cytokines are the ones that will help my sun damaged skin. And plant stem cells make no sense at all for human skin. Nothing natural about that when you think about it.

free skin care · Fri Feb 10, 2012 6:56 am

Firefox7275 wrote:

It is not a state secret, there are details on the blog if you are minded to double check http://barefacedtruth.com/?page_id=95

Does he have free time or is he laying the foundation of their USP, doing market research? Who else would you have 'publicise' the blog? It has to be a scientist to remain legitimate, to remain 'truthful'. If they get this right word of mouth will be a powerful marketing tool, the buzz on forums could translate to press coverage. I see the current situation as a win-win: when else are we going to have this level of knowledge at our disposal?

Actually, Firefox, you have made my point exactly. This is what I think he is doing, laying the foundation and doing marketing. So, if that is the "barefacedtruth" why not come right out and say that? I would rather have him be honest up front than look sneaky in the end.

Also, I have double checked, and there is no where that gives his credentials. Before you became so enamored with the good doctor, did you check out his credentials at all?

free skin care · Fri Feb 10, 2012 11:55 am

rileygirl wrote:

Firefox7275 wrote:

It is not a state secret, there are details on the blog if you are minded to double check

Does he have free time or is he laying the foundation of their USP, doing market research? Who else would you have 'publicise' the blog? It has to be a scientist to remain legitimate, to remain 'truthful'. If they get this right word of mouth will be a powerful marketing tool, the buzz on forums could translate to press coverage. I see the current situation as a win-win: when else are we going to have this level of knowledge at our disposal?

Actually, Firefox, you have made my point exactly. This is what I think he is doing, laying the foundation and doing marketing. So, if that is the "barefacedtruth" why not come right out and say that? I would rather have him be honest up front than look sneaky in the end.

Also, I have double checked, and there is no where that gives his credentials. Before you became so enamored with the good doctor, did you check out his credentials at all?

I see somebody has been talking about me in my absence. As I keep saying, I am not the issue. (And I do note that you don't seem to be asking for the credentials of all those industry scientists or pitchmen). But all that aside, I have nothing to hide. There is a bio. page but I cannot give you the link. Maybe someone else could do that (if someone PM's me I'll give it to them).

However I also wonder whether talking about my professional background is going to resolve your suspicions about my motivations for being here. So let me be clear (believe me or not). I am not here not to promote myself or any product. I am here on a mission, the one you will see amply displayed at barefacedtruth. BFT is a nonprofit site (notice the ads and product sales here; not complaining, just want you to be able to see the contrast). BFT will never take ads or sell products. Heck, we don't even test them. You won't find us hawking our own products there either. Our company will have its own site, its own marketing team, its own samples & user trials. We keep them separate from BFT. What we do there is examine the science. Most products on the market break down when you examine their claims and find that they defy all known physiology. They do junk science, get junk results. Sometimes we look more closely to try and understand why they are doing what they do. We even invite them to debate us publicly (debate in science is good). Now, where you seem to take issue is that we have day jobs, a company working on products in this very realm. Well, that is precisely how we got interested in the first place, and why we have gathered all this knowledge, and why we are PO'd at the junk.

Am I marketing? No. This would be the most inefficient form of marketing known to man. The CEO spends an hour a day talking to a half dozen superusers? Not going to sell enough to justify his time. Know how products in this realm get sold? You advertise. Spend a buck, make 2. Spend $1M, make $2M. Better yet, start a MLM scheme. That way you get your salespeople to spend the ad dollars.

Am I doing market research? Not in a formal sense, but informally I suppose I learn a lot from you guys. I learn what you like & dislike. I learn especially because when you ask me challenging questions, and I have to go back to the literature & textbooks, or consult with an expert, in order to answer. So I get educated along with you. That is why I am here. I won't always have the time, that is true. For now I am enjoying myself.

free skin care · Fri Feb 10, 2012 3:18 pm

aswong wrote:

rileygirl: I also cannot find the doctors credentials on the web.
The test results of Lifeline has be subjectively tested by BioScreen.
(Skin hydration by Corneometer — 93% demonstrated statistically significant improvement
Skin elasticity by Cutometer — 73% showed significant improvement
Skin brightness by Chromameter — 63% showed significant improvement
Appearance of fine lines and coarse wrinkles — 66% reported significant improvement.) BioScreen is registered with the United States Food and Drug Administration (FDA) and the Drug Enforcement Agency (DEA) and is ISO 9001 certified.
Dr. Manny Alvarez and Fox News' Health Talk reported that studies prove that Lifeline's stem cell extracts deliver results similar to collagen injections.
ISCO is associated with 8 reputable research institutes such as UC San Francisco and Irvine etc.
ISCO has given numerous presentations to reputable stem cell conferences.

BFT explanations of science why Lifeline do not work maybe misleading.

I would like to have more evidence about George Taylor, M.D.'s and John Sanderson, M.D.'s expertise in stem cell research or published paper. I am patiently waiting!

First, aswong has entirely mischaracterized BFT's discussion of Lifeline. BFT is looking at Lifeline but has not yet seen basic things like a list of ingredients. We criticized on marketplace execution, like an uninformative website. We pointed to very precarious financial condition (they are publicly traded on the pink sheets. Then in the end we said that we wanted the products to work, and hoped for more information. We work with stem cells, we know their power.

Second, aswong has ignored the post above his/hers in which I said there wqas a complete bio. available, but that I do not have privileges to post URL's here. They screen them out. If aswong wants to PM me, I would be happy to share the URL.

Third, aswong give the marketing laundry list. May all be true, but to date nobody has supplied me with the studies. Seems like aswong is more concerned with checking me out than checking out the company claims.

I think turnabout is fair play. I would like to request aswong share the same information with me. What is your relationship with ISCO? You seem to want to defend the party line, but why? Are you part of the company? Are you an investor concerned about the falling stock price?

You have my disclosures, and can have my full bio. Can we have yours?

I'm patiently awaiting ...

free skin care · Fri Feb 10, 2012 8:24 pm

Here is Dr. J's full bio

http://barefacedtruth.com/biography-of-a-really-mad-scientist

free skin care · Fri Feb 17, 2012 9:23 am

missz wrote:

Our VP, Simon Craw, PhD, spoke on Friday with Dr. John Sanderson so that the two could speak directly. One of the things that they spoke about was whether human parthenogenetic stem cells are better than other types. Our position on this is:

The best stem cells are pluripotent (meaning that they can differentiate into other cell types and are effectively immortal).

Embryonic stem cells are pluripotent, but they also are controversial. Should laboratories be creating and destroying embryo’s for the benefit of skincare? We’ll leave the ethics of that up to others to decide, but we choose to not go there.

Parthenogenetic (the word is Greek for “virgin birth”) stem cells begin with an oocyte but are not fertilized with sperm—so lacking the Y chromosome, can never mature in a living being. They have the same potency as an embryonic stem cell, without the ethical complications.

IPS (or induced pluripotent stem cells) are being used for research. In this process, genes are manipulated to a more primitive state. When genomes are manipulated, the consequences are unknown.

Mesenchymal (or adult) stem cells have a lower concentration of growth factors and cytokines.

Are there alternatives to Lifeline’s parthenogenetic stem cells? Yes, there are. Lifeline is the product of International Stem Cell Corporation, which developed and patented the non-embryonic stem cells.

As for our clinical studies—we have published the results of both in vivo and in vitro studies in a brochure that was created for skincare professionals. If you would like to see a pdf of that brochure (which includes the studies), please email me at zmillar@intlstemcell.com

Hi missz,

Allow me to correct something here. I did have a very pleasant conversation with Dr. Craw, and we agreed on many things. But as to whether parthenogenic stem cells are superior to mesenchymal or other stem cells in the context of farming cytokines and growth factors, Dr Craw did not state that at all. In fact I asked him that question directly, and his answer was a clear and simple no, that is not his position. Your company had never tested different cell types, and so he would no basis for such a conclusion. He went on to explain that parthenogenic cells were the platform your company works with exclusively and that the reasons for that are not directly related to the cytokine topical applications we are talking about here, but rather with rather with issues about immunity which relates to cell implants. That was the answer that made sense, and I applaud him for his transparency. (I did so also in an ISCO update on BFT after our conversation). I suggest you talk to Dr Craw again about this.

The whole topic of superiority of cell types is a bit misleading anyway. Harvesting cytokines is not tissue transplantation. There a thousand ways to manipulate cells in culture to increase or decrease cytokine expression. I think the pattern of cytokines may be far more interesting the total yield. (<--theory)

Also your suggesting an equivalency between the terms "adult" and "mesenchymal" stem cells is incorrect. Mesenchymal designates a particular class of stem cells. There are other adult stem cells types that are adult but not mesenchymal.

You also state that pluripotent stem cells are better. Again, that may be true in a different context. I just don't think you can make that argument effectively when the task is cell culture farming for cytokines.

You also state (correctly) that in IPS, genes are manipulated to a more primitive state, and that when genomes are manipulated, the consequences are unknown. But cannot the same be said for the creation of your own cell lines? They also are induced (parthenogenetically-induced pluripotent stem cells is another term). I may be incorrect here, so ask you to educate me. Do parthenogenetic stem cells exist in nature? Or are they induced from the inner cells of an oocyte, just as fertilized embryonic stem cells are induced from the inner cells of the blastocyst?

You again state "mesenchymal ... stem cells have a lower concentration of growth factors and cytokines.". Again, unless you have a basis for that statement, I would avoid making it part of your pitch. Besides which, it is easy to concentrate these things, if indeed more is better.

Also, several people here have asked about the number of subjects in the clinical study. It is not mentioned in the brochure. Could you provide that please?

Thank you in advance, missz. You seem to be a strong advocate for your company. These clarifications will help us to avoid confusion as we try to more fully grasp the nature and impact of the very important work that you are doing.

free skin care · Tue Feb 21, 2012 12:28 am

erg wrote:

I got my samples as well. I am going to order a dermaroller to help with penetration of this lotion. I am hoping that might make a difference. There is NO way I can afford $190 (a month) - but I am hoping that 3x per week used with a dermaroller might be enough to make a difference. Again, I would be using a 25m dermaroller.

I think you will find a bottle will last you more than a month Wink

so it's not that extreme Very Happy

I have the Night Serum and I'm using it morning and night - I only need 1 pump for each application - 2 pumps is just overkill and I end up looking yellow and it goes a bit beady - so 1 pump is just right for me - people may quiry whether 1 pump is as effective as 2 but as long as you have sufficient coverage it is enough - the skin can only absorb so much, anything more and it just sits on top and is a waste Wink

free skin care · Tue Feb 21, 2012 6:42 pm

jom wrote:

riley, how did you get samples of these products? TIA

Here you go Jom:

AmazingLife wrote:

I think we're in luck...just pulled this from the lifeline website faq's:

"Do you offer free samples?

Beginning February 2012, we will be offering free samples of Lifeline Nighttime Serum. If you would like to receive a sample, send an email to customercare@lifelineskincare.com, giving us your name and mailing address. If you would like to be notified about special offers, you can also sign up for our newsletter."

free skin care · Thu Feb 23, 2012 3:56 pm

erg wrote:

I got my samples as well. I am going to order a dermaroller to help with penetration of this lotion. I am hoping that might make a difference. There is NO way I can afford $190 (a month) - but I am hoping that 3x per week used with a dermaroller might be enough to make a difference. Again, I would be using a 25m dermaroller.

I'm not sure if I'll ever get around to purchasing a dermaroller - it kinda scares me! lol Laughing

I'm not a fan of pain... hahaha... Very Happy

But I recently got a Clarisonic Mia for the purpose of greater penetration of my skincare products. Wink

And so far I'm loving the combination of the Night Serum used in conjunction with the Clarisonic Cool

Fri Feb 24, 2012 11:11 am

erg wrote:

I got my samples as well. I am going to order a dermaroller to help with penetration of this lotion. I am hoping that might make a difference. There is NO way I can afford $190 (a month) - but I am hoping that 3x per week used with a dermaroller might be enough to make a difference. Again, I would be using a 25m dermaroller.

Hi erg,

The core technology of Lifeline Skin Care comes from our parent company, International Stem Cell Corporation--where most of their time and energy is spent on developing stem cell lines for the treatment of regenerative diseases including neurological disabilities, liver disease, blindness, pancreatic disease and skin aging. That being said, our core competency is developing renewable sources of replacement cells to treat Parkinson's, diabetes, and related conditions and disabilities--truthfully, we haven't studied how the stem cell extracts work when used in combination with a dermaroller.

When we developed Lifeline Skin Care, our initial efforts were, well, less than successful. The formulators weren't able to stabilize the extracts. The current formula (see my previous post on the nanospheres) ensures that the actives are delivered to the skin.

So the truthful answer is: we don't know. Maybe other people who have more experience there can enlighten us... we're open to all good ideas that will enhance results.

free skin care · Mon Mar 05, 2012 11:10 am

DarkMoon wrote:

rileygirl wrote:

DarkMoon wrote:

riley is this one you ever got a chance to try or no...so much catching up to do on my part! Laughing

Hi, DM! Yes, I purchased the Lifeline night serum when I had the discount code that came with the samples I got. I held off using it for a while, as I wanted to make sure my skin was in good condition (not dry, eczema under control) before I started the product. I actually just started my trial with it yesterday.

My ultimate goal here (money allowing) would be to use 1 bottle of Lifeline (and I am only using 1 pump twice a day, which is more than enough to cover my face), and then try Dr. J's new product and see how each of these 2 lines work. I have taken before photos for my trial with Lifeline and if I have anything to show, I'll post B/A's when my trial is done.

Thanks Riley,

I missed out on ordering samples, not sure if that is still possible?
I will be anxiously awaiting your (and everyone's) results.
I along with erg wonder when Dr.J's company will be releasing their product and at what price???? Very Happy

Hi DM, you can still get samples. I just got mine last week. It took about a week to get them. I haven't tried the product yet.

Here's the info:

Beginning February 2012, we will be offering free samples of Lifeline Nighttime Serum. If you would like to receive a sample, send an email to customercare@lifelineskincare.com, giving us your name and mailing address. If you would like to be notified about special offers, you can also sign up for our newsletter."

free skin care · Mon Mar 05, 2012 4:41 pm

GLOW sounds great! I read somewhere about a study where participants were asked to guess age. The one factor that stood out is that a face tends to look older when there is less glow or clarity. This was more of factor than wrinkles. Give me some GLOW! I am getting super tempted.
Smile

free skin care · Mon Mar 05, 2012 8:54 pm

Happens to the best of us, DM! Laughing

Thu Mar 08, 2012 1:47 pm

DarkMoon wrote:

jom wrote:

DarkMoon wrote:

After emailing, I called just to see if I could possibly get 2 night samples instead of day and night (not fond of chemical SS). I mentioned to the sales rep. why and he told me they are looking into making a ss free version of the day serum. I also inquired about just using the night version and was told that all the actives needed were in the night serum and the day was to protect those actives during the day.....not sure that is a necessity or if any moisturizer would do the same?

Both of the samples I got were of the night serum.

I think most received one each, but I could be mistaken....would not be the first time! Shock

Hi DarkMoon,

You are correct, at this time Lifeline Skin Care is offering free samples only of our Recovery Night Moisture Serum. We will keep you posted if we will have also our Day cream available for testing.

free skin care · Thu Mar 08, 2012 5:15 pm

Nicotinamide is notorious for causing flushing. A short google session will get you lots of info about that.

free skin care · Fri Mar 09, 2012 6:10 pm

Glamcat wrote:

Lacy53 wrote:

Glamcat wrote:

Nicotinamide and Niacin can and do cause flushing in sensitive individuals -- however there seems to be some confusion here with the use of the word Niacinamide. Niacinamide is the no flush version ---

I am confused so please enlighten me ... what's the difference (in your opinion) between Nicotinamide and Niacinamide?

This is not my opinion - it's just the fact. There is plenty of information regarding this on the internet - it just needs a quick google. Wink

Here's my "quick google":

Niacinamide - Compound Summary (CID 936)

Also known as: nicotinamide, 3-Pyridinecarboxamide, vitamin PP, Aminicotin, Amixicotyn, Nicotinic acid amide, Papulex, Nicotylamide, Endobion

Molecular Formula: C6H6N2O
Molecular Weight: 122.12464

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=936

If Niacinamide is different from Nicotinamide in your opinion, then it doesn't seem to agree with "facts".

free skin care · Wed Mar 14, 2012 2:45 pm

Lifeline has a patent Pub. No.: WO/2012/018865 for the following:

Topical compositions containing lysate of human parthenogenetic stem cells (hpSCs), preferably within a liposomal dispersion, that reduce the visible signs of skin aging and/or cellulite.

You can read all the details about how they make their lysate of human parthenogenetic stem cells including what they do with the media.

http://www.wipo.int/patentscope/search/en/detail.jsf?docId=WO2012018865

free skin care · Fri Mar 16, 2012 12:05 pm

New testimonial video on the Lifeline:

http://www.lifelineskincare.com/page/66/Video-Product-Reviews.html

Also, for anyone interested in using the Lifeline with Retin A:

"It’s fine to introduce Lifeline to your regimen. Both products work to accomplish the same objective (anti-aging benefits), but do so in different ways. So they’re complementary— not competitive. A few special rules apply, however…

Here’s what both tretinoin and Lifeline do:

Increase cellular turnover
Cause a healthy proliferation of new cells
Help support the production of collagen and elastin
Reduce wrinkles and hyperpigmentation; increase skin firmness

Here’s how they work:

Tretinoin (known commonly as Retin-A, Retin-A Micro, or Renova) is very specific—it targets retinoic acid receptors in the skin, which then signal the cells to increase and accelerate skin cell turnover.

Pluripotent stem cell extracts (as found in Lifeline Skin Care) are much more broad spectrum. They send messaging molecules to a more complex set of genes that regulate the expression level of elastin, collagen, and various growth factors.

We recommend giving both products the chance to be fully absorbed. Apply the Retin-A first, wait a minute or two, and then apply the Lifeline on top of it."
(http://www.lifelineskincare.com/blog/2012/03/for-years-i-have-used-prescription-retinoids-should-lifeline-be-used-in-addition-to-retin-a-or-instead-of-it/?utm_source=Newsletter&utm_medium=Email&utm_campaign=March%2BNewsletter)

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