Inflammaging
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free skin care · Wed Jun 06, 2012 4:40 pm

I love this paper.

Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory

Aging, and especially human aging, can be explained by the emerging concept of parainflammation-driven inflammaging, i.e. a combination of inflammation and aging. Inflammaging posits that aging either physiologically or pathologically can be driven by the pro-inflammatory cytokines and substances produced by the innate immune system. Animals must maintain homeostasis as they age despite incessant attack from both intrinsic and extrinsic stimuli/antigens. These potentially harmful pro-inflammatory signals at a later stage of life may act antagonistically to the beneficial role they had in an earlier stage of life, like serving as developmental engines for body system formation. The concept of inflammaging is based on an antagonistic pleiotropy theory programmed during evolution. Clinical trials including caloric restriction, sirtuin activators, and p38 MAPK inhibitors against both pathological aging such as metabolic syndrome, diabetes mellitus, rheumatoid arthritis, and Werner syndrome and physiological aging have been proposed.

Here is the full text pdf. Let's talk.

http://www.biosciencetrends.com/action/downloaddoc.php?docid=169

free skin care · Thu Jun 07, 2012 10:07 am

Barefootgirl wrote:

With respect to calorie restriction, aren't adequate protein and essential fatty acids the primary concern?

Of course, plant phytochemicals and fiber are nice to have around, but the body doesn't break down as quickly without those as it does in the absence of protein and certain fats?

BFG

If you are restricting kilocalories then you are restricting macronutrients. There are various responses: firstly break down stored fat or 'stored' protein (muscle). Secondly convert dietary macronutrients to the form required - protein can be converted to carbs for energy. Thirdly conserve nutrients by down-regulating non-essential processes. Different deficiencies have different effects, it's not simply a case of how quickly tissue is destroyed or rebuilt but the quality of the skin cells/ hormones/ plasma produced. We are not all here on EDS simply looking at whether our skin cells function as a barrier, keeping major infection out and enough water in that we don't die of dehydration.

Depending how much someone is restricting kilocalories and over how long a period, it's quite challenging to get all the micro and macro nutrients in optimal quantities, especially if one is fuelling an active lifestyle or active hobbies. Yes, I am aware some also believe in restricting physical activity for longevity but bluntly we evolved to move. And, no, comparing the average American/ UK diet to a calorie restricted one is not a valid argument - no health professional recommends the average American/ UK diet for wellbeing.

HTH! Smile

free skin care · Thu Jun 07, 2012 12:47 pm

This article suggests another way to get some of the benefits of caloric restriction:
http://www.economist.com/node/21543129
Autophagy - "This process, whose name is derived from the Greek for "self-eating", is a mechanism by which surplus, worn-out or malformed proteins and other cellular components are broken up for scrap and recycled."
I wish I could measure my autophagy performance Very Happy

And I'll take exercising over a near-starvation diet any day!!!

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