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Thu Jun 14, 2012 2:09 pm  |
| Q: What would be a good travel size? How many day's worth would suit most people? |
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Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Thu Jun 14, 2012 2:31 pm |
| DrJ wrote: |
| Q: What would be a good travel size? How many day's worth would suit most people? |
For me, at least enough to cover a fortnight's holiday, plus a little extra to be on the safe side, would be perfect.
ETA: I forgot that most people outside of the UK don't use the term "fortnight" - sorry! A fortnight means 2 weeks.  |
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Thu Jun 14, 2012 2:48 pm |
| majorb wrote: |
| DrJ wrote: |
| Q: What would be a good travel size? How many day's worth would suit most people? |
For me, at least enough to cover a fortnight's holiday, plus a little extra to be on the safe side, would be perfect.
ETA: I forgot that most people outside of the UK don't use the term "fortnight" - sorry! A fortnight means 2 weeks. |
From the Old English fēowertyne niht, meaning "fourteen nights". I can hear the accent now. Mind you, my mother is visiting, and her British accent never faded one iota, so my ears are tuned to that channel. My favorite is "dirty weekend". She uses that one a lot, my mum does. |
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Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Thu Jun 14, 2012 4:51 pm |
http://www.newdirectionsaromatics.com/airless-dispenser-mini-bottles-black-white-p-1550.html
Hi Dr. J, I would like a weeks worth in a travel bottle size. If I needed more I could take two. Above is a link to airless sample bottles that might work. I have ordered some but have not used them yet. I'm sure there are other ones also. One of the downfalls of this bottle is it can not be refilled. |
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Everything has beauty but not everyone sees it |
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Thu Jun 14, 2012 5:01 pm |
| CookieD wrote: |
http://www.newdirectionsaromatics.com/airless-dispenser-mini-bottles-black-white-p-1550.html
Hi Dr. J, I would like a weeks worth in a travel bottle size. If I needed more I could take two. Above is a link to airless sample bottles that might work. I have ordered some but have not used them yet. I'm sure there are other ones also. One of the downfalls of this bottle is it can not be refilled. |
Rockey ordered some too. His team is testing all sorts - but these look very cool. Thanks! |
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Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Thu Jun 14, 2012 6:26 pm |
What tremendous news for people with MS to give them hope! To think that maybe in the not too distant future that MS could be a disease of the past. Very exciting the breakthroughs that are coming forth! |
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Fri Jun 15, 2012 3:27 am |
| DrJ wrote: |
| From the Old English fēowertyne niht, meaning "fourteen nights". I can hear the accent now. Mind you, my mother is visiting, and her British accent never faded one iota, so my ears are tuned to that channel. My favorite is "dirty weekend". She uses that one a lot, my mum does. |
I'd better not ask why your mum keeps talking about dirty weekends!  
I do like that you call her "mum" instead of "mom". |
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Fri Jun 15, 2012 8:14 am |
Which is more convenient - we can make up travel sizes of products for sale, or we could stock and give away upon request travel size containers that you guys could fill yourselves. Your preference? |
_________________
Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Fri Jun 15, 2012 9:35 am |
Majorb, Those bottles look really good and it's a huge plus that you can refill them. I'm always looking for something small to travel with because right now I take 2 little plastic bags worth of stuff and give 1 of them to my husband to take through security at the airport for me. |
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Everything has beauty but not everyone sees it |
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Fri Jun 15, 2012 10:00 am |
| DrJ wrote: |
Which is more convenient - we can make up travel sizes of products for sale, or we could stock and give away upon request travel size containers that you guys could fill yourselves. Your preference? |
I think it would be a great gesture, not to mention much more economical, if you could possibly give away a travel size container upon request, please, Dr J.
I've actually ordered some of the ones in the ebay link so I can try them out. I'll be away for the weekend next month and will need to travel light. It'll be a good opportunity to see how well they work. |
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Fri Jun 15, 2012 10:03 am |
| CookieD wrote: |
| Majorb, Those bottles look really good and it's a huge plus that you can refill them. I'm always looking for something small to travel with because right now I take 2 little plastic bags worth of stuff and give 1 of them to my husband to take through security at the airport for me. |
I know that feeling only too well, CookieD. It's just as well that our husbands aren't as vain as we are - what a disaster it would be to be married to someone who insists on using their own full plastic bag allocation!  |
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Fri Jun 15, 2012 12:34 pm |
Very interesting. "Activate" is similar to what we do in biomimetic cytokine farming of MSC's. They conclude that these MSC-derived therapies are especially useful in "older population groups". Presumably humans as well as mice. 
J Surg Res. 2012 May 29.
Activated mesenchymal stem cells increase wound tensile strength in aged mouse model via macrophages.
Lee S, Szilagyi E, Chen L, Premanand K, Dipietro LA, Ennis W, Bartholomew AM. Department of Surgery, University of Illinois, Chicago, Illinois.
Abstract
BACKGROUND:
Wound healing is impaired in the aged. Mesenchymal stem cells (MSCs) can exert beneficial effects in wounds; however, promoting healing in the challenging setting of aged skin may require additional potency. MSCs can enhance the production of pro-regenerative cytokines and growth factors when activated with interferon gamma. We hypothesized that the increased potency of activated MSC could be used to facilitate wound healing in the aged mice.
METHODS:
Young and old C57BL6 mice underwent incisional wounds and were treated with naive MSCs, activated MSCs, or vehicle to examine MSC effects on tensile strength in the aged skin. To test whether the benefits of MSC treatment could be attributed to the participation of host macrophages, liposomal clodronate was used to deplete host macrophages.
RESULTS:
In older mice, tensile strength of healing wounds was significantly lower than that in younger mice. Older mice treated with activated MSCs showed significant increases in tensile strength restoring the strength to that observed in younger mice. Macrophage depletion abrogated the beneficial effect of MSC.
CONCLUSIONS:
Activated MSCs restored wound tensile strength in the aged mice, and this effect was dependent on host macrophage activity. These data provide encouraging support for the development of activated MSC therapies for enhanced tissue regeneration, especially for older population groups. |
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Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Fri Jun 15, 2012 4:14 pm |
| RussianSunshine wrote: |
| Ok, I got the serum today and paid $30 taxes. Holy crap. |
I wonder if having EDS offer this product if that would help on all these extra fees to those in Canada? |
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The best way to locate your cat is to open a can of food. |
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Fri Jun 15, 2012 4:40 pm |
| Frodo wrote: |
| RussianSunshine wrote: |
| Ok, I got the serum today and paid $30 taxes. Holy crap. |
I wonder if having EDS offer this product if that would help on all these extra fees to those in Canada? |
They are duties & VAT taxes, I believe. So somebody would get stuck with it. I have proposed a rebate program. It is being deliberated. |
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Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Fri Jun 15, 2012 4:54 pm |
| But every country has its own method of taxation. In Australia we get slugged the GST and we pay much more for skincare, toiletries, perfumes etc (which are considered luxury items) than the US. However, our authorities don't appear to be policing internet purchases in the same way as Canada . |
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Born 1950. There's a new cream on the market that gets rid of wrinkles - you smear it on the mirror!! |
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Fri Jun 15, 2012 5:01 pm |
| Keliu wrote: |
| But every country has its own method of taxation. In Australia we get slugged the GST and we pay much more for skincare, toiletries, perfumes etc (which are considered luxury items) than the US. However, our authorities don't appear to be policing internet purchases in the same way as Canada . |
I think different countries police internet purchases differently at different times. I remember when the US was confiscating Internet drug purchases from Canada and at other times they didn't care. |
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Everything has beauty but not everyone sees it |
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Fri Jun 15, 2012 5:14 pm |
| CookieD wrote: |
| Keliu wrote: |
| But every country has its own method of taxation. In Australia we get slugged the GST and we pay much more for skincare, toiletries, perfumes etc (which are considered luxury items) than the US. However, our authorities don't appear to be policing internet purchases in the same way as Canada . |
I think different countries police internet purchases differently at different times. I remember when the US was confiscating Internet drug purchases from Canada and at other times they didn't care. |
I purchase all my meds from an international website and they usually get opened and scrutinized by customs. But I've never had a package confiscated or been charged a fee. Toiletries seem to make it through without any hassle. |
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Born 1950. There's a new cream on the market that gets rid of wrinkles - you smear it on the mirror!! |
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Fri Jun 15, 2012 5:19 pm |
Dr. J (says): Look! (showing Mum his laptop screen and reads outloud):
| DrJ wrote: |
Very interesting. "Activate" is similar to what we do in biomimetic cytokine farming of MSC's. They conclude that these MSC-derived therapies are especially useful in "older population groups". Presumably humans as well as mice.
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Mum (says): Well done, son. Keep working on it in your lab. (scurries off to nibble some cheese)
(She pauses, turns around and squeaks): Don't forget to fill up my AnteAGE plastic gallon bottle, I'm running low.
Dr. J: Sure thing.
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Fri Jun 15, 2012 5:22 pm |
| Keliu wrote: |
| CookieD wrote: |
| Keliu wrote: |
| But every country has its own method of taxation. In Australia we get slugged the GST and we pay much more for skincare, toiletries, perfumes etc (which are considered luxury items) than the US. However, our authorities don't appear to be policing internet purchases in the same way as Canada . |
I think different countries police internet purchases differently at different times. I remember when the US was confiscating Internet drug purchases from Canada and at other times they didn't care. |
I purchase all my meds from an international website and they usually get opened and scrutinized by customs. But I've never had a package confiscated or been charged a fee. Toiletries seem to make it through without any hassle. |
It happened a couple of years ago. I don't know if they are still doing it or not but it was a big story here for awhile. People were not taking their meds because they ran out and customs didn't let the new medicine come though. It was all about the cost difference of the same drug here vs someplace else. They were also concerned about counterfeit drugs but I think it was mostly about money.
Sorry went off topic.  |
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Everything has beauty but not everyone sees it |
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Fri Jun 15, 2012 10:41 pm |
| CookieD wrote: |
| Keliu wrote: |
| CookieD wrote: |
| Keliu wrote: |
| But every country has its own method of taxation. In Australia we get slugged the GST and we pay much more for skincare, toiletries, perfumes etc (which are considered luxury items) than the US. However, our authorities don't appear to be policing internet purchases in the same way as Canada . |
I think different countries police internet purchases differently at different times. I remember when the US was confiscating Internet drug purchases from Canada and at other times they didn't care. |
I purchase all my meds from an international website and they usually get opened and scrutinized by customs. But I've never had a package confiscated or been charged a fee. Toiletries seem to make it through without any hassle. |
It happened a couple of years ago. I don't know if they are still doing it or not but it was a big story here for awhile. People were not taking their meds because they ran out and customs didn't let the new medicine come though. It was all about the cost difference of the same drug here vs someplace else. They were also concerned about counterfeit drugs but I think it was mostly about money.
Sorry went off topic. |
Not off topic. Subtopic, maybe. No topic policemen in sight.
Tomorrow is "YOU CHOOSE THE TOPIC" day around here. A few helpful suggestions, but you can add your own:
--penetration of actives - including maybe some talk about how we make lipo-nanos & why)
--stem cell niches (key differences between fat-, marrow-, and other-derived stem cells and their cytokines & what that really means)
--total formulation jigsaw puzzles. If the piece don't fit, don't acquit. |
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Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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Sat Jun 16, 2012 12:55 pm |
| DrJ wrote: |
Tomorrow is "YOU CHOOSE THE TOPIC" day around here. A few helpful suggestions, but you can add your own:
--penetration of actives - including maybe some talk about how we make lipo-nanos & why)
# 2) --stem cell niches (key differences between fat-, marrow-, and other-derived stem cells and their cytokines & what that really means)
# 3) --total formulation jigsaw puzzles. If the piece don't fit, don't acquit. |
re: #2: In my opinion, you've posted sufficient info per substantiated lab study sources about the differences. Very appreciative.
re: #3: In my opinion, the formulation jigsaw puzzle is such a quagmire for skin product manufacturers that they simply give up and 'throw in the towel' and make skin products with an 'everything including the kitchen sink' ingredient list because they are just as confused as what's good and might work and what's not and doesn't. |
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Sat Jun 16, 2012 1:10 pm |
| DrJ wrote: |
Not off topic. Subtopic, maybe. No topic policemen in sight.
Tomorrow is "YOU CHOOSE THE TOPIC" day around here. A few helpful suggestions, but you can add your own:
--penetration of actives - including maybe some talk about how we make lipo-nanos & why)
--stem cell niches (key differences between fat-, marrow-, and other-derived stem cells and their cytokines & what that really means)
--total formulation jigsaw puzzles. If the piece don't fit, don't acquit. |
Well, ok, I’m taking your offer and I am choosing my topic. As far as I am concerned, you don’t need to post any more studies as to the wonder of BMSC cytokines. It’s getting kind of old, and I get it. They are great! They are the future of skin care. They are significantly superior to any other active that we have today. They make any and all other skin care treatments better. I get it. And while I can’t speak for other members of the forum, I think they get it too. There are probably not many forum members out there that need any more convincing. The ones that feel comfortable spending $280 on a product have likely already done so. So instead of trying to entice with science, I believe that the way to increase your product sales is to offer a three month introductory special that drops the price by 50% (both products for $140). Yes, I know that is a lot, but the product will now become both affordable and acceptable to a much wider audience. You keep the introductory special running for three months – put a little clock on the screen counting down the time – and by the end of the three months you should have a lot of people hooked – so you can go back to the original price and you shouldn’t see too much of degradation in sales. I do believe that you believe in this product and the technology, and I think this is a way of showing it.
And at the risk of sounding like a total nut case, I want to add that I believe that truth in skin care is totally subjective. The science is always appreciated, but we make our own truth. |
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Sat Jun 16, 2012 2:51 pm |
| Kath91 wrote: |
| DrJ wrote: |
Tomorrow is "YOU CHOOSE THE TOPIC" day around here. A few helpful suggestions, but you can add your own:
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re: #2:
re: #3: |
# 4: here's an older, carefree lady,
concerned about skin care, but,
- appears to not be concerned about ingredients in the products she uses, (haven't watched her entire v-blog),
- does not seem OBSESSED about the INGREDIENT labels of the skin products she uses,
- probably would not have read scientific journals or studies about ingredients she puts on her face,
but,to me, her over-55 skin looks quite healthy. She uses what she believes works for her.
http://www.youtube.com/watch?v=U4k5FharA7Q
I only hope my continued usage of Anteage will be so simple. |
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Sat Jun 16, 2012 4:17 pm |
| Panda1 wrote: |
| DrJ wrote: |
Not off topic. Subtopic, maybe. No topic policemen in sight.
Tomorrow is "YOU CHOOSE THE TOPIC" day around here. A few helpful suggestions, but you can add your own:
--penetration of actives - including maybe some talk about how we make lipo-nanos & why)
--stem cell niches (key differences between fat-, marrow-, and other-derived stem cells and their cytokines & what that really means)
--total formulation jigsaw puzzles. If the piece don't fit, don't acquit. |
Well, ok, I’m taking your offer and I am choosing my topic. As far as I am concerned, you don’t need to post any more studies as to the wonder of BMSC cytokines. It’s getting kind of old, and I get it. They are great! They are the future of skin care. They are significantly superior to any other active that we have today. They make any and all other skin care treatments better. I get it. And while I can’t speak for other members of the forum, I think they get it too. There are probably not many forum members out there that need any more convincing. The ones that feel comfortable spending $280 on a product have likely already done so. So instead of trying to entice with science, I believe that the way to increase your product sales is to offer a three month introductory special that drops the price by 50% (both products for $140). Yes, I know that is a lot, but the product will now become both affordable and acceptable to a much wider audience. You keep the introductory special running for three months – put a little clock on the screen counting down the time – and by the end of the three months you should have a lot of people hooked – so you can go back to the original price and you shouldn’t see too much of degradation in sales. I do believe that you believe in this product and the technology, and I think this is a way of showing it.
And at the risk of sounding like a total nut case, I want to add that I believe that truth in skin care is totally subjective. The science is always appreciated, but we make our own truth. |
Not a total nut. I can agree strongly with you about the subjective being a main purchasing determinant. But what we are finding is that it is changing. We daily encounter women who are hungry for somethbing beyond the sub jective - they want to to think of cosmecuticals like they do drugs their doctor precribes. They want to have a sense of confidence that there is real science built in, not just the fluffy marketing, fairy tale kind. We are getting a real boost from estheticians, who want their own professional standing to be elevated to something "evidence based" , not just experience in-the-moment based. They have become our closest allies in the battle for truth-in-cosmetic-advertising. Our fellow docs were always there (well, most of them).
Pricing is always a delicate issue. Mind you, I agree in principle with the idea that we want to get this into as many hands as possible. We have some thoughts on that in the works. Beyond that my lips are sealed, so don't ask! |
_________________
Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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