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The Aloe Vera causes aging - glycation debate?
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skincareaddicted
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Fri Nov 23, 2007 12:49 pm      Reply with quote
I don't want to alarm everyone, but there was talk about aloe vera and glycation on the skin interactive board a while back.

I didn't pay particular attention at the time because i wasn't using any products very frequently with very much aloe. The reason I am interested now is because my new favorite sunscreen (Devita Solar Protective Moisturizer 30) has aloe vera listed as the second ingredient.

I haven't researched extensively on this but have read some articles here and there.

Here is an excerpt from http://forum.lef.org/default.aspx?f=38&m=17177 :

Quote:
Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

Besides glucose, other reducing sugars, such as mannose, react with proteins to form advanced glycosylation end-products (AGEs), that are active in cross-linking collagen and elastin, the process that causes skin aging...


I admit i don't really understand the sciency part of this and was wondering what everyone's thoughts/interpretations are.

Kris

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maiea
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Sat Nov 24, 2007 2:28 am      Reply with quote
I'm kinda confused - because those 2 paragraphs don't seem like they make sense together? Wound healing is normally associated with anti-aging products (and aloe is long believed to be good for the skin, and that seems to support that).

And mannose and mannose-6-phosphate although they may sound similar are quite different molecules.

Mannose:
http://en.wikipedia.org/wiki/Mannose

Mannose-6-phosphate:
http://en.wikipedia.org/wiki/Mannose-6-phosphate

My guess is both statements are right - mannose-6-phosphate being beneficial, while mannose isn't?
annachan
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Sat Nov 24, 2007 7:13 am      Reply with quote
I just know that when I make my own cleansers or toners with aloe my skin looks so much better ....also I just read 'Aloe vera also protects our skin from exposure to ultra-violet radiation' .......
havana8
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Sat Nov 24, 2007 7:16 pm      Reply with quote
Aloe Vera & Glycation -- A Review of the Scientific Literature
http://www.nancykbrown.com/images/stories/Aloe%20Vera%20a%20review%20of%20the%20scientific%20literature.pdf
annachan
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Sat Nov 24, 2007 7:22 pm      Reply with quote
ok so as far as that says it is an internal process and it doesnt seem that aloe would do that at all ....' Amount of Caloric Intake – “age-related
accumulation of AGE is more closely related to
[the amount of] caloric intake ...than a specific
dietary carbohydrate” present in the diet.'
interesting! and yet another reason to cut down on sugar!
damn! Rolling Eyes
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Sat Nov 24, 2007 8:32 pm      Reply with quote
havana8 wrote:
Aloe Vera & Glycation -- A Review of the Scientific Literature
http://www.nancykbrown.com/images/stories/Aloe%20Vera%20a%20review%20of%20the%20scientific%20literature.pdf


Good enough for me - thanks for posting that. So in the review it basically says Aloe Vera is anti-glycation due to all the other beneficial components in it. Now I have even more reason to use aloe. Very Happy
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Tue Nov 27, 2007 2:15 pm      Reply with quote
oh, thanks for all the replies. i will look at the link you posted Havana on my next break. Thanks!

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