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Thu Jun 14, 2012 11:41 am  |
Platelet Rich Plasma has a long history of use for delayed wound healing, and as enhancers in many types of surgical procedures. More recently there has been interest in PRP for facial esthetics. I thought it would be worthwhile to explore how this stuff works, especially in light of recently popularized procedures like "vampire lifts" (injected autologous platelet concentrate lysates).
Let's start with this paper which provides a good review. The discussion part is a good review of dermal & epidermal cell:cell interactions.
Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229934/pdf/ad-23-424.pdf
Note also the the discussion of MMP-1 and MMP-3.... aPRP and aPPP showed an increase in the expression of MMP-1 and MMP-3 protein. MMPs digesting various structural components of the ECM are centrally involved in dermal remodelling. Similar induction of MMP-1 in photoaged skin may facilitate the removal of collagen fragments that damage the dermal matrix tissue, thus providing a better foundation for the deposition of new collagen aPRP may induce
Does this raise any issues, esthetically speaking? Are there other issues with PRP that come to mind? |
_________________
Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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havana8
Moderator
 
Joined: 09 Sep 2005
Posts: 3449
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Fri Jun 15, 2012 8:17 am |
| DrJ wrote: |
| The active ingredients in platelet rich plasma are cytokines and growth factors released from platelets. Why would the results with PRP (lysed platelet) injections be any different than deep needling plus targeted cytokine cocktails? Not sure how much PRP has been discussed around here. Interesting stuff. I'll start a new thread so as not to overwhelm this one. |
| mountaingirl wrote: |
| I look forward to hearing your thoughts DrJ. I'm very interested in the comparison of PRP to deep rolling. The only difference my novice mind can conclude, is that the cytokines and growth factors in PRP would be more concentrated when injected in specific areas of the face (?) |
| Tiny wrote: |
| Of course they would! Your getting the direct batch from your own blood! In away its like apples and oranges here, the skincare is topical and will take alot of time to do "there thing", these are a direct shot in, can only mean, its quicker, faster, and all around better results. I cannot see how the two could compare, other than a poor mans version perhaps. You'll get results fast, me using the cytokines I am, will, take A LOT longer. |
| DarkMoon wrote: |
Plus they are using your own?
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| mountaingirl wrote: |
I just wondered if deep rolling in specific area's would simulate the PRP. I appreciate any and all info as simply-put-as-possible since I am not the sharpest pencil in the science box.  |
| DrJ wrote: |
There are certain cytokines concentrated in platelets, that is true. It's because platelets are key to the first wave of wound healing. e.g. after you get a cut. But these same cytokines are ubiquitous in the human body. So its possible to isolate them not just from platelets, but from other cells, including certain stem cells involved in healing. But you can replicate the dose of these you get from injection of PRP merely by concentrating the key cytokines, which you can do several ways. Then dermarolling is to some extent a mimic for injection (you get a pretty wide open path) but not exactly the same. Then there are newer dermal needling techniques that better mimic injections. Needs some good studies, but in theory all the pieces are there.
Human cytokines and growth factors are natural, and yours are identical to every other humans. Platelets on the other hand have antigens. These can stimulate production of antibodies against other people's antigens which can cause major problems. By coming up with a "platelet-free" type of PRP (get rid of cells, just use the cytokines; the right ones, at the right place, at the right time", you get the benefits without the worries, and it will be a lot cheaper.
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| Tiny wrote: |
Color me confused, how in the world can a derma roller mimic an injection ! I get it "should" in theory, allow product to penetrate
"better"! But penetrate better and INJECT, are two different animals.
Your inferring if others use your product and derma roll, they too can achieve this. I do NOT see how adding a derma roll, to Re Luma, is going to give me the same results as this "more" invasive procedure. |
| DrJ wrote: |
I didn't mention any product, I'm talking concept. But since you mention ReLuma I should point out that ReLuma uses adipose-derived stem cells to create cytokines, and therefore will not contain some of the key cytokines present within PRP. Contrast this with bone marrow derived MSC's which are key regulators of platelet production in vivo (one of their many roles) and share cytokine and growth factor concentration gradients with them. In fact in some experimental protocols, you have to add PRP to adipose stem cells in order to acheieve a stem cell paracrine effect.
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| Lotusesther wrote: |
The subject is the vampire lift, which is not done with a derma roller. I assume there must be a reason for that.
Furthermore I don't see why adipose stem cells (naturally present in our cheeks) would not send the right messages and bone marrow stem cells would. So far the user's reviews do seem to be slightly in favour of the fat, not the bone when it comes to skin effects. |
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havana8
Moderator
Joined: 09 Sep 2005
Posts: 3449
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Fri Jun 15, 2012 8:26 am |
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Fri Jun 15, 2012 8:42 am |
| Lotusesther wrote: |
| The subject is the vampire lift, which is not done with a derma roller. I assume there must be a reason for that. |
You could do a vampire lift with a dermaroller, but because it is expensive to do the PRP separation(requires special equipment) injections are done to avoid wasting any of the resulting plasma .concentrate. In fact because needling itself induces collagen production, theoretically you might get additive effects combined with PRP.
| Lotusesther wrote: |
| Furthermore I don't see why adipose stem cells (naturally present in our cheeks) would not send the right messages and bone marrow stem cells would. So far the user's reviews do seem to be slightly in favour of the fat, not the bone when it comes to skin effects. |
Bone marrow derived mesenchymal stem cells are intimately involved with hematopoesis (formation of blood elements) including platelet production. Therefore they contain the same cytokines as PRP (lysed platelets). Stem cells from fat do not share this characteristic. The scientific literature shows you have to add PRP to adipose stem cell medium to get some of the same effects as that already present in marrow-derived stem cell medium. Fat stem cells are not part of the body's natural "911" repair system, and so are not the same as the marrow derived ones. Thanks for asking. |
_________________
Physician - scientist - curmudgeon. Kind to animals and stem cells. Nonprofit muckraking site: www.barefacedtruth.com. Day job: www.anteage.com |
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