| Author |
Message |
|
|
|
Wed Apr 18, 2007 3:07 pm  |
Emma just reminded me in another thread so I thought I'd post.
The first part which shows pro-collagen synthesis is only in vitro, but interesting.
Effect of Camellia japonica oil on human type I procollagen production and skin barrier function.
Type I collagen is the primary component of the skin dermis. Both the quantity and quality of extracellular collagen are primarily related to skin ageing. In this study, we investigated the possibility that Camellia japonica oil (CJ oil) may be introduced as an anit-wrinkle agent. As a first step to this end, human COL1A2 promoter luciferase assay was performed in human dermal fibroblast cells. CJ oil was determined to activate human COL1A2 promoter in a concentration-dependent manner. In consistency with this result, while matrix metalloproteinase (MMP)-1 activity was inhibited by CJ oil, human type I procollagen synthesis was also induced by CJ oil. These results suggest the possibility that CJ oil may be involved in the skin ageing. For the evaluation of CJ oil's safety and efficiency on human skin, human skin primary irritation test and trans-epidermal water loss (TEWL) were performed. Transepidermal water loss (TEWL) was measured before treatment then, 1h and 2h after treatment; the forearm site was selected to measure TEWL. Also, a human skin primary irritation test was performed on the normal skin (upper back) in 30 volunteers to see if a certain material included in CJ oil has irritation or sensitization potential. In these assays, CJ oil reduced trans-epidermal water loss (TEWL) and did not induce any adverse reactions. Therefore, based on these results, we suggest the possibility that CJ oil may be considered as possible wrinkle-reducing candidates for topical application.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17386986&query_hl=2&itool=pubmed_docsum |
|
|
|
|
|
Wed Apr 18, 2007 6:44 pm |
I always keep luciferase nearby to throw at trolls. (if you want a good eBay source, I'll hook you up.)
Molly, the keywords for pubmed searches sometimes get lost when you post links. If anyone is familiar with the MMP they mention, please share what you know. |
|
|
|
|
|
Wed Apr 18, 2007 7:58 pm |
if memory serves me correctly, mmp stands for metallo-something proteinases (helpful, i know)...but the bottom line is that they degrade collagen, so anything that stops them from activating is a good thing.  |
|
|
|
|
|
Wed Apr 18, 2007 10:28 pm |
As Youngrace says the MMP thing stops collagen degrading. It's a very common term if you're into the science behind actives: a whole host of anti-oxs and retinoids do this.
I thought it was interesting to see a scientific study of a natural oil for a change because there are very few.
If you plug Camellia oil into the search query on pubmed you'll find it, but I pasted all there is over anyhow.
(what is this pink line about trolls?!) |
|
|
|
|
|
Thu Apr 19, 2007 6:40 am |
LOL, sorry, it wasn't about you! I just came across the word luciferase in your abstract and started giggling. I just wanted to make a silly joke with it. Come on: Luciferase! 
The actual word for mmp -- matrix metalloproteinase -- is in the abstract as well. I really wasn't sure if the inhibition they described was a "good" thing or bad -- thank you both much for the explanation. |
|
|
|
|
|
Thu Apr 19, 2007 7:34 am |
Molly-Thanks for bringing this study to our attention.
WARNING!!! Entering nerd territory that has nothing to do with the topic of this thread.....
I couldn't help but look up luciferase and it is an enzyme involved in bioluminesence. Here is a little write up on bioluminesence that discusses the role of luciferase. Since my childhood this phenomenon has totally fascinated me and the link below provides a nice explanation.
http://www.lifesci.ucsb.edu/~biolum/chem/index.html
Here is one search result for luciferase assay. A little technical but since the study on Camelia oil used an assay of this sort I thought I would see what it is.
http://www.promega.com/tbs/tb281/tb281.html |
|
|
|
|
|
Thu Apr 19, 2007 12:47 pm |
I am a secret nerd and I read Pubmed articles all the time. There is another site called Herbal Science Research which searches Pubmed articles specific to botanicals - http://www.herbalscienceresearch.com/
Actually if you search either by common or latin name of a plant species you are interested in there will most likely be many articles about the antioxidant properties of the plant, which could possible be applied to the skincare context. |
|
|
|
|
|
Thu Apr 19, 2007 11:01 pm |
Thanks for the link Miranets. I do tend to come across 'claims' for these things but not much in the way of hard and fast evidence.
Maybe I should be using the Latin names so thanks I hadn't realised. I'll do some searching this weekend because I'm in the nerdy club too when it comes to skin stuff at least  |
|
|
|
|
| Wed Nov 26, 2025 6:11 am |
If this is your first visit to the EDS Forums please take the time to register. Registration is required for you to post on the forums. Registration will also give you the ability to track messages of interest, send private messages to other users, participate in Gift Certificates draws and enjoy automatic discounts for shopping at our online store. Registration is free and takes just a few seconds to complete.
Click Here to join our community.
If you are already a registered member on the forums, please login to gain full access to the site. |
|
 |
|
